JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB174554

Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus)

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 213 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

FAIM1, FAIM, Fas apoptotic inhibitory molecule 1

1 이미지
SDS-PAGE - Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) (AB174554)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) (AB174554)

15% SDS-PAGE analysis of ab174554 (3 μg).

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

style
left-column

보완 제품

Primary Antibodies

AB215191

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

  • 5
  • 4
Proteins & Peptides

AB164800

Recombinant Human TMEM116 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human TMEM116 protein (GST tag N-Terminus) (AB164800)

  • 0
  • 0
Primary Antibodies

AB184787

Anti-Caspase-3 antibody [EPR18297]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-3 antibody [EPR18297] (AB184787)

  • 3
  • 3
Primary Antibodies

AB209845

Anti-GSDMD antibody [EPR19828]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-GSDMD antibody [EPR19828] (AB209845)

  • 4
  • 3
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLLPFIRTLPLLCYNHLLVSPDSATLSPPYSLEKMTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGAAKTKATINIDAISGFAYEYTLEINGKSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGIIHTLIVDNREIPEIAS","proteinLength":"Full Length","predictedMolecularWeight":"26.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":213,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NVQ4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FAIM1 also known as Fas Apoptotic Inhibitory Molecule 1 inhibits apoptosis. This protein has a molecular mass of approximately 24 kDa and comes from expression in various tissues with significant presence in the brain liver and immune cells. FAIM1 blocks apoptotic signals triggered via the Fas receptor also called CD95 ensuring cell survival under certain challenging conditions.
Biological function summary

Functions of FAIM1 support anti-apoptotic activities independent of death receptor pathways. It participates in cellular responses to stress like oxidative stress. The protein does not seem to form a complex but interacts with proteins involved in cell death regulation such as Fas-associated proteins to modulate stress response and survival signaling pathways.

Pathways

FAIM1 shows involvement in apoptosis-related pathways and affects the NF-κB signaling. The protein acts in the molecular framework by inhibiting signals from the Fas receptor collaborating with proteins such as FLIP which also regulate cell death pathways. FAIM1 further influences signaling through NF-κB essential in modulating the immune response.

Research links FAIM1 to neurodegenerative diseases like Alzheimer's disease due to its protective effects against apoptotic cell death. Connections exist between FAIM1 and increased cell survival involving proteins like Bcl-xL which enhance the survival of neurons in stressful environments. FAIM1 also associates with cancer where its overexpression could relate to increased tumor cell survival detailing interactions with oncogenic pathways.
style
left-column

일반 정보

기능

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

서열 유사성

Belongs to the FAIM1 family.

style
left-column

제품 프로토콜

style
left-column

타겟 정보

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.
See full target information FAIM
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com