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AB176049

Recombinant Human FANK1 protein (His tag N-Terminus)

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Recombinant Human FANK1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 345 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

HSD13, UNQ6504/PRO21382, FANK1, Fibronectin type 3 and ankyrin repeat domains protein 1

1 이미지
SDS-PAGE - Recombinant Human FANK1 protein (His tag N-Terminus) (AB176049)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human FANK1 protein (His tag N-Terminus) (AB176049)

15% SDS-PAGE analysis of 3µg ab176049.

주요 정보

Purity

>85% SDS-PAGE

ab176049 is purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Proteins & Peptides

AB174559

Recombinant Human SSSCA1 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human SSSCA1 protein (denatured) (His tag N-Terminus) (AB174559)

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Proteins & Peptides

AB174421

Recombinant Human TAZ protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human TAZ protein (denatured) (His tag N-Terminus) (AB174421)

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Proteins & Peptides

AB177632

Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein I (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein I (denatured) (His tag N-Terminus) (AB177632)

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Proteins & Peptides

AB176082

Recombinant Human CGT protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human CGT protein (denatured) (His tag N-Terminus) (AB176082)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEPQKIMPPSKPHPPVVGKVTHHSIELYWDLEKKAKRQGPQEQWFRFSIEEEDPKMHTYGIIYTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKSCVC","proteinLength":"Full Length","predictedMolecularWeight":"40.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":345,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8TC84","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FANK1 also known as FANK1 precursor is a protein encoded by the FANK1 gene and has a mass of approximately 55 kDa. Mechanically FANK1 has a role in the regulation of gene expression during spermatogenesis with its action specific to cells in the testis where it is highly expressed. The target is most active in the meiotic and post-meiotic phases of sperm cell development indicating its specialized function in male reproductive biology. FANK1’s expression pattern suggests its function closely ties to the development of male gametes.
Biological function summary

The function of FANK1 relates to regulation within the reproductive system where it acts as part of a regulatory network controlling genes vital for sperm maturation. This protein coordinates the expression of a set of target genes necessary for spermatid differentiation and function. Although it does not appear to be part of larger protein complexes FANK1 influences the transcriptional regulation directly essential for proper progression of spermatogenesis. This suggests a tightly controlled mechanism governing male fertility.

Pathways

FANK1 participates in the spermatogenesis pathway impacting the series of events that leads to the production of mature sperm cells. It has connections with other proteins like SYCP3 within the meiotic prophase pathway influencing structural alterations necessary for successful meiosis. The coordination between these proteins ensures correct chromosomal behavior during cell division essential for generating viable sperm.

FANK1 can be connected to male infertility particularly when disruptions occur in spermatogenesis. Aberrant expression or mutations in FANK1 correlate with impaired sperm development and reduced male fertility. This protein shows a disease-associated interaction with transcriptional regulators involved in testicular function further illustrating its importance in maintaining reproductive health. The intricate relationship of FANK1 with spermatogenic pathways reflects its involvement in maintaining the balance required for normal reproductive potential.
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일반 정보

기능

Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.

Post-translational modifications

Polyubiquitinated. Polyubiquitination leads to proteasomal degradation.

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제품 프로토콜

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타겟 정보

Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.
See full target information FANK1
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Product promise

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