Recombinant Human FCRL1 protein (His tag) is a Human Fragment protein, in the 1 to 303 aa range, expressed in HEK 293 cells, with >98%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
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CD307a, FCRH1, IFGP1, IRTA5, FCRL1, Fc receptor-like protein 1, FcR-like protein 1, FcRL1, Fc receptor homolog 1, IFGP family protein 1, Immune receptor translocation-associated protein 5, FcRH1, hIFGP1
- SDS-PAGE
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SDS-PAGE - Recombinant Human FCRL1 protein (His tag) (AB276402)
SDS-PAGE analysis of ab276402
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
FCRL1 serves an important role in modulating the B cell receptor (BCR) signaling. It does not form part of a larger receptor complex but interacts directly with components of the BCR. This interaction affects the activation thresholds of B cells helping to fine-tune immune responses. FCRL1 supports maintaining immune homeostasis by balancing the activation and inhibition of B cells.
Pathways
FCRL1 participates actively in the BCR signaling pathway and is involved in modulating the MAPK/ERK pathway. FCRL1 interacts with signaling molecules related to these pathways such as SHP-1 which can modulate downstream effects. By adjusting these signaling dynamics FCRL1 indirectly influences processes central to adaptive immune responses linking it to other receptor family members like FcγRs.
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기능
Type I transmembrane surface glycoprotein preferentially expressed by B-cells that regulates BCR-mediated signaling responses (PubMed : 15479727). Recruits ABL1 as the intracellular effector molecule to enhance B-cell activation (By similarity). Also plays a negative role by suppressing ERK activation under homeostatic and BCR-stimulated conditions in a GRB2-dependent manner (By similarity).
Post-translational modifications
Phosphorylated on tyrosines upon activation.
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