Recombinant human FGR protein (GST tag N-Terminus)
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- FuncS
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Functional Studies - Recombinant human FGR protein (GST tag N-Terminus) (AB60854)
Sample Kinase Activity Plot.
- FuncS
Unknown
Functional Studies - Recombinant human FGR protein (GST tag N-Terminus) (AB60854)
The specific activity of FGR (ab60854) was determined to be 155 nmol/min/mg as per activity assay protocol
- SDS-PAGE
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SDS-PAGE - Recombinant human FGR protein (GST tag N-Terminus) (AB60854)
SDS PAGE analysis of ab60854
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human FGR protein (GST tag N-Terminus) (AB60854)
ab60854 on SDS-PAGE, MW ~86 kDa.
보완 제품
Reagents, Controls & Accessories
AB325997
Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color)
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특성 및 보관 정보
제형
Purification 테크닉
배송 시 보관 조건
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적절한 장기 보관 조건
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The FGR protein impacts processes related to immune responses and cell communication. It participates in the formation of multi-protein complexes enabling interactions that mediate pathways important for cellular signaling. Through these interactions the FGR protein controls important processes like cell growth differentiation and movement especially in immune cell types. Its role in signal transduction renders it a critical player in various immune functions.
Pathways
The FGR protein integrates into the signaling networks such as the MAPK/ERK pathway and PI3K/AKT pathway which are pivotal for cell survival and proliferation. Within these pathways FGR interacts with other proteins like the GRB2 and PI3K to mediate downstream effects that influence many cellular responses. These interactions ensure that alterations in external signals lead to appropriate cellular outcomes sustaining a balance in cellular behavior and immune functions.
일반 정보
기능
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity).
서열 유사성
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Post-translational modifications
Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation.. Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
Subcellular localisation
Cytoskeleton
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Product promise
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