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AB86853

Recombinant Human FUS2 protein (His tag N-Terminus)

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Recombinant Human FUS2 protein (His tag N-Terminus) is a Human Full Length protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.
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SDS-PAGE - Recombinant Human FUS2 protein (His tag N-Terminus) (AB86853)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FUS2 protein (His tag N-Terminus) (AB86853)

15% SDS-PAGE showing ab86853 (3μg).
Note : Real molecular weight on SDS-PAGE is shifted up compared to predicted molecular weight.

주요 정보

Purity

>95% SDS-PAGE

ab86853 is purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q93015-1

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 5 Constituents: 30% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.39% MES

storage-buffer

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보완 제품

Primary Antibodies

AB279392

Anti-Ago1 antibody [OTI4G1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ago1 antibody [OTI4G1] (AB279392)

  • 0
  • 0
Proteins & Peptides

AB109940

Recombinant Human DRG1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human DRG1 protein (His tag N-Terminus) (AB109940)

  • 0
  • 0
Proteins & Peptides

AB167828

Recombinant Human PSTPIP1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human PSTPIP1 protein (His tag N-Terminus) (AB167828)

  • 0
  • 0
Primary Antibodies

AB96051

Anti-PML Protein antibody [C7]

BOND RX™ Validated|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-PML Protein antibody [C7] (AB96051)

  • 5
  • 3
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMQELTLSPGPAKLTPTLDPTHRMELILSTSPAELTLDPACQPKLPLDSTCQPEMTFNPGPTELTLDPEHQPEETPAPSLAELTLEPVHRRPELLDACADLINDQWPRSRTSRLHSLGQSSDAFPLCLMLLSPHPTLEAAPVVVGHARLSRVLNQPQSLLVETVVVARALRGRGFGRRLMEGLEVFARARGFRKLHLTTHDQVHFYTHLGYQLGEPVQGLVFTSRRLPATLLNAFPTAPSPRPPRKAPNLTAQAAPRGPKGPPLPPPPPLPECLTISPPVPSGPPSKSLLETQYQNVRGRPIFWMEKDI","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q93015","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FUS2 also known as Fusion 2 is a protein that plays a role in DNA repair and recombination. It has an approximate molecular mass of 55 kDa. This protein gets expressed in a variety of tissues but shows particular expression in neuronal cells. FUS2 functions as a nuclear protein helping to maintain genome stability by participating in the post-replication DNA repair process.
Biological function summary

FUS2 contributes to the homology-directed repair pathway. It functions as a part of a larger protein complex involved in detecting and resolving DNA double-strand breaks. The protein interacts with other repair proteins facilitating the correct alignment and processing of DNA during repair. This biological role ensures the maintenance of genomic integrity in cells.

Pathways

FUS2 is an integral component of the DNA damage response pathway. This pathway involves several proteins including BRCA1 and RAD51 which work together to detect and repair DNA damage. FUS2's activity in this pathway ensures effective repair of double-strand breaks reducing the likelihood of mutations and genomic instability.

Mutations or dysregulation of FUS2 link to neurodegenerative disorders like Amyotrophic Lateral Sclerosis (ALS). Altered FUS2 function impacts neurons potentially through its interaction with TDP-43 a protein implicated in ALS. Additionally FUS2 dysregulation can contribute to cancer development connected to proteins like p53 that help control cell cycle and apoptosis. These connections highlight FUS2's importance in maintaining cellular health.
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일반 정보

기능

N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed : 29581253, PubMed : 30028079). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed : 29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed : 29581253, PubMed : 30028079). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed : 10644992, PubMed : 29581307). May act as a tumor suppressor (PubMed : 10644992).

서열 유사성

Belongs to the acetyltransferase family.

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제품 프로토콜

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타겟 정보

N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed : 29581253, PubMed : 30028079). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed : 29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed : 29581253, PubMed : 30028079). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed : 10644992, PubMed : 29581307). May act as a tumor suppressor (PubMed : 10644992).
See full target information NAA80

대체 명칭 보기

FUS2, NAT6, NAA80, N-alpha-acetyltransferase 80, HsNAAA80, N-acetyltransferase 6, Protein fusion-2, Protein fus-2
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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