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AB276378

Recombinant Human G6b protein (Fc Chimera)

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Recombinant Human G6b protein (Fc Chimera) is a Human Fragment protein, in the 1 to 146 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

C6orf25, G6B, G6B-B, MPIG6B, Megakaryocyte and platelet inhibitory receptor G6b, Protein G6b

1 이미지
SDS-PAGE - Recombinant Human G6b protein (Fc Chimera) (AB276378)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human G6b protein (Fc Chimera) (AB276378)

SDS-PAGE analysis of ab276378

주요 정보

Purity

>95% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

Fc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS

storage-buffer

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보완 제품

Primary Antibodies

AB320579

PE Anti-CD44 antibody [SP37]

RabMAb|Recombinant

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Proteins & Peptides

AB275562

Recombinant Human GPBB protein (Tagged)

SDS-PAGE - Recombinant Human GPBB protein (Tagged) (AB275562)

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Primary Antibodies

AB272253

PerCP/Cy5.5® Anti-CD24 antibody [M1/69]

Flow Cytometry - PerCP/Cy5.5® Anti-CD24 antibody [M1/69] (AB272253)

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Primary Antibodies

AB284389

Anti-CD133 antibody [RM1029]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD133 antibody [RM1029] (AB284389)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIP","proteinLength":"Fragment","predictedMolecularWeight":"40.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":146,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O95866","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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일반 정보

기능

Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed : 12665801, PubMed : 17311996, PubMed : 27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed : 12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6 : FcRgamma signaling (PubMed : 17311996). Appears to operate in a calcium-independent manner (PubMed : 12665801).. Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.

Post-translational modifications

All isoforms are N-glycosylated.. Isoform E is O-glycosylated.. Phosphorylated.

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제품 프로토콜

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타겟 정보

Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed : 12665801, PubMed : 17311996, PubMed : 27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed : 12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6 : FcRgamma signaling (PubMed : 17311996). Appears to operate in a calcium-independent manner (PubMed : 12665801).. Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.
See full target information MPIG6B
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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