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AB218080

Recombinant human GDF11 protein (Active)

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Recombinant human GDF11 protein (Active) is a Human Full Length protein, in the 299 to 407 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, FuncS.

대체 명칭 보기

BMP11, GDF11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11, BMP-11

2 이미지
Functional Studies - Recombinant human GDF11 protein (Active) (AB218080)
  • FuncS

Unknown

Functional Studies - Recombinant human GDF11 protein (Active) (AB218080)

Functional analysis of ab218080

SDS-PAGE - Recombinant human GDF11 protein (Active) (AB218080)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human GDF11 protein (Active) (AB218080)

SDS-PAGE analysis of ab218080 at 1 μg under (1) non-reducing and (2) reducing conditions in a 4-20% Tris-Glycine gel, stained with Coomassie Blue. Human GDF11 is a homodimer with a total; predicted MW of 24.9 kDa (each monomer 12.4 kDa).

주요 정보

Purity

>95% SDS-PAGE

발현 시스템

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Alkaline phosphatase activity induced in ATDC-5 cells.

Acceptance Criteria: ED50 ≤100 ng/mL(≥ 1.0 x 104 units/mg).

Accession

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute at 0.1 mg/mL in 10 mM HCl

보관 버퍼

Constituents: 0.1% Trifluoroacetic acid

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB325994

Prestained Protein Ladder - Mid-range molecular weight (11-180 kDa, 4-color)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (11-180 kDa, 4-color) (AB325994)

  • 0
  • 0
Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

  • 5
  • 8
Proteins & Peptides

AB283413

Recombinant Mouse MSTN Protein

Mass Spectrometry - Recombinant Mouse MSTN Protein (AB283413)

  • 0
  • 0
Sample Prep & Detection Kits

AB102890

HRP Conjugation Kit - Lightning-Link®

Conjugation - HRP Conjugation Kit - Lightning-Link® (AB102890)

  • 4
  • 3
Sample Prep & Detection Kits

AB201795

Biotinylation Kit / Biotin Conjugation Kit (Fast, Type A) - Lightning-Link®

ELISA - Biotinylation Kit / Biotin Conjugation Kit (Fast, Type A) - Lightning-Link® (AB201795)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

This product shares 100% homology with amino acids 297-405 of Rat and Mouse GDF11.

This product was previously labelled as BMP11, BMP11 + GDF8 / Myostatin

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서열 정보

[{"linker":null,"sequence":"NLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS","proteinLength":"Full Length","predictedMolecularWeight":"12.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":407,"aminoAcidStart":299,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O95390","tags":[]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
True
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일반 정보

기능

Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed : 31215115). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed : 28257634).

서열 유사성

Belongs to the TGF-beta family.

Post-translational modifications

Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases (PubMed:31215115). This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase.

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제품 프로토콜

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타겟 정보

Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed : 31215115). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed : 28257634).
See full target information GDF11
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

BMC research notes 18:195 PubMed40275319

2025

The influence of the geroprotective cytokine on the transcriptome of young and senescent mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Liya G Kondratyeva,Diana K Matveeva,Maria I Ezdakova,Marina V Utkina,Andrey Yu Ratushnyy
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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