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AB239555

Recombinant Human GLP-1R protein (His tag)

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Recombinant Human GLP-1R protein (His tag) is a Human Fragment protein, in the 24 to 145 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

Glucagon-like peptide 1 receptor, GLP-1 receptor, GLP-1-R, GLP-1R, GLP1R

1 이미지
SDS-PAGE - Recombinant Human GLP-1R protein (His tag) (AB239555)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GLP-1R protein (His tag) (AB239555)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel analysis of ab239555.

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Yeast

Tags

6x His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: 10% Glycerol (glycerin, glycerine), 2.9% Sodium chloride, 0.32% Tris HCl

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB234617

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB234617)

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Assay Kits

AB65336

Triglyceride Assay Kit - Quantification

Biochemical assay - Triglyceride Assay Kit - Quantification (AB65336)

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Primary Antibodies

AB218532

Anti-GLP-1R antibody [EPR21819]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Frozen sections) - Anti-GLP-1R antibody [EPR21819] (AB218532)

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Proteins & Peptides

AB235719

Recombinant Human GLP-1 protein (Tagged)

SDS-PAGE - Recombinant Human GLP-1 protein (Tagged) (AB235719)

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Proteins & Peptides

AB276649

Recombinant Human GIP protein (Fc Chimera)

SDS-PAGE - Recombinant Human GIP protein (Fc Chimera) (AB276649)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"sequence":"RPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLY","proteinLength":"Fragment","predictedMolecularWeight":"16.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":145,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"P43220","tags":[{"tag":"6x His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GLP-1R also known as glucagon-like peptide-1 receptor plays an important role in glucose metabolism. This receptor is a member of the class B family of G protein-coupled receptors (GPCRs) and has a molecular mass of approximately 53 kDa. GLP-1R is expressed in pancreatic beta cells the central nervous system and other peripheral tissues. It binds to GLP-1 a peptide hormone initiating a cascade of intracellular signaling that is essential for its physiological functions.
Biological function summary

GLP-1R serves as an important player in the regulation of insulin secretion. It is not part of a complex but acts as a standalone receptor. When GLP-1 binds to GLP-1R it triggers the activation of adenylyl cyclase increasing cyclic AMP levels and facilitating insulin secretion. This process is glucose-dependent meaning that it enhances insulin release only when blood glucose levels are elevated therefore preventing hypoglycemia.

Pathways

GLP-1R is an integral component of the incretin signaling pathway and the insulin signaling pathway. Through these pathways it influences key metabolic processes. Incretin hormones like GLP-1 improve glucose-dependent insulin secretion involving proteins such as GLP-1R and other incretin-related receptors. Additionally GLP-1R interacts with insulin receptor pathways to modulate glucose uptake in tissues.

GLP-1R has significant implications in type 2 diabetes and obesity. Its role in enhancing insulin secretion makes it a target for therapeutic interventions using GLP-1 analogs like liraglutide. Liraglutide structure mimics natural GLP-1 effectively agonizing GLP-1R to achieve desired metabolic outcomes. Additionally liraglutide GLP-1 analog therapies show promise in obesity management by influencing appetite regulation through GLP-1R pathways in the central nervous system.
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일반 정보

기능

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed : 19861722, PubMed : 26308095, PubMed : 27196125, PubMed : 28514449, PubMed : 7517895, PubMed : 8216285, PubMed : 8405712). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed : 19861722, PubMed : 26308095, PubMed : 27196125, PubMed : 28514449, PubMed : 7517895, PubMed : 8216285, PubMed : 8405712). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).

서열 유사성

Belongs to the G-protein coupled receptor 2 family.

Post-translational modifications

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.

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제품 프로토콜

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타겟 정보

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed : 19861722, PubMed : 26308095, PubMed : 27196125, PubMed : 28514449, PubMed : 7517895, PubMed : 8216285, PubMed : 8405712). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed : 19861722, PubMed : 26308095, PubMed : 27196125, PubMed : 28514449, PubMed : 7517895, PubMed : 8216285, PubMed : 8405712). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
See full target information GLP1R
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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