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AB113595

Recombinant Human GPD1L protein (His tag N-Terminus)

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(1 출판물)

Recombinant Human GPD1L protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 351 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

KIAA0089, GPD1L, Glycerol-3-phosphate dehydrogenase 1-like protein, GPD1-L

1 이미지
SDS-PAGE - Recombinant Human GPD1L protein (His tag N-Terminus) (AB113595)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPD1L protein (His tag N-Terminus) (AB113595)

15% SDS-PAGE analysis of ab113595 (3μg)

주요 정보

Purity

>95% SDS-PAGE

ab113595 was purified using conventional chromatography.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB110413

Total OXPHOS Rodent WB Antibody Cocktail

Western blot - Total OXPHOS Rodent WB Antibody Cocktail (AB110413)

  • 5
  • 18
Assay Kits

AB115102

Histone H3 Acetylation Assay Kit

ELISA - Histone H3 Acetylation Assay Kit (AB115102)

  • 4
  • 2
Primary Antibodies

AB14748

Anti-ATP5A antibody [15H4C4] - Mitochondrial Marker

BOND RX™ Validated|Lab Essentials

Western blot - Anti-ATP5A antibody [15H4C4] - Mitochondrial Marker (AB14748)

  • 5
  • 27
Primary Antibodies

AB203832

Anti-UQCRC2 antibody [EPR13051]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRC2 antibody [EPR13051] (AB203832)

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  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT","proteinLength":"Full Length","predictedMolecularWeight":"40.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":351,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8N335","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein GPD1L also known as glycerol-3-phosphate dehydrogenase 1-like protein plays an enzymatic role in converting L-glycerol-3-phosphate to dihydroxyacetone phosphate while reducing NAD+ to NADH. Its molecular mass is approximately 39 kDa. GPD1L is expressed in the heart muscle and various other tissues. Its expression levels vary depending on the tissue indicating different roles in various biological environments.
Biological function summary

GPD1L affects several metabolic processes which are essential for cellular energy balance and homeostasis. It does not form a known complex but interacts with cellular components influencing metabolic flux. By acting as part of redox reactions it helps in maintaining the balance of redox states in cells. It also affects ion channels by modulating sodium current density in cardiac tissues which is important for heart function.

Pathways

GPD1L participates in metabolic and signaling pathways. It is integral to the glycerophosphate shuttle pathway helping in transferring reducing equivalents into mitochondria for ATP production. In addition it has a role in cardiac conduction and regulation of ion channels particularly in conjunction with the protein SCN5A which affects sodium ion flow and heart rhythm.

GPD1L is linked to cardiac arrhythmias such as Brugada syndrome. Mutations in the GPD1L gene can disrupt sodium current which is often associated with irregular heartbeats and increased risk of sudden cardiac death. Its relationship with the SCN5A protein is significant as mutations in SCN5A also contribute to similar cardiac conditions by affecting sodium channel function and predisposition to arrhythmias.
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일반 정보

기능

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.

서열 유사성

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

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제품 프로토콜

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타겟 정보

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
See full target information GPD1L
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in oncology 15:1582728 PubMed40538846

2025

GPD1L downregulation in colorectal cancer: a novel obesity-related biomarker linking metabolic dysregulation to tumor progression.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Zhu,Huiyuan Li,Hongzhang Liu,Yusheng Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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