Recombinant Human GPNMB protein (denatured) (His tag N-Terminus)
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Recombinant Human GPNMB protein (denatured) (His tag N-Terminus) is a Human Fragment protein, in the 22 to 474 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
대체 명칭 보기
HGFIN, NMB, UNQ1725/PRO9925, GPNMB, Transmembrane glycoprotein NMB, Hematopoietic growth factor inducible neurokinin-1 type
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human GPNMB protein (denatured) (His tag N-Terminus) (AB171588)
15% SDS-PAGE analysis of ab171588 at 3µg.
보완 제품
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
배송 시 보관 조건
적절한 단기 보관 기간
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GPNMB plays versatile roles in promoting cell growth differentiation and repair. It is involved in processes like tissue regeneration possibly due to its role in cell adhesion and migration. The protein also partakes in osteoclast differentiation and bone resorption therefore linking to skeletal homeostasis. GPNMB forms part of a broader protein complex at the cellular junctions interacting with integrins to mediate its functions.
Pathways
GPNMB features prominently in osteoclastogenesis and melanoma metastasis pathways. It cooperates with RANKL an important protein in bone metabolism by influencing osteoclast differentiation and activation. In the context of melanoma GPNMB's action in pathways may enhance tumor proliferation and invasion possibly interacting with signaling molecules like AKT or ERK although the specifics remain actively researched.
일반 정보
기능
Could be a melanogenic enzyme.
서열 유사성
Belongs to the PMEL/NMB family.
Subcellular localisation
Early endosome membrane
Product promise
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