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AB164438

Recombinant Human GRWD1 protein (GST tag N-Terminus)

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Recombinant Human GRWD1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 446 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

GRWD, KIAA1942, WDR28, GRWD1, Glutamate-rich WD repeat-containing protein 1

1 이미지
SDS-PAGE - Recombinant Human GRWD1 protein (GST tag N-Terminus) (AB164438)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GRWD1 protein (GST tag N-Terminus) (AB164438)

ab164438 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Primary Antibodies

AB52943

Anti-Vimentin (phospho S82) antibody [EP1071Y]

RabMAb|Lab Essentials

Western blot - Anti-Vimentin (phospho S82) antibody [EP1071Y] (AB52943)

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Primary Antibodies

AB176815

Anti-GRWD1 antibody

Immunoprecipitation - Anti-GRWD1 antibody (AB176815)

  • 0
  • 0
Proteins & Peptides

AB139213

Recombinant Human IFN-alpha-7 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human IFN-alpha-7 protein (denatured) (His tag N-Terminus) (AB139213)

  • 0
  • 0
Primary Antibodies

AB283655

Anti-iNOS antibody [RM1017]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-iNOS antibody [RM1017] (AB283655)

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  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MAARKGRRRTCETGEPMEAESGDTSSEGPAQVYLPGRGPPLREGEELVMDEEAYVLYHRAQTGAPCLSFDIVRDHLGDNRTELPLTLYLCAGTQAESAQSNRLMMLRMHNLHGTKPPPSEGSDEEEEEEDEEDEEERKPQLELAMVPHYGGINRVRVSWLGEEPVAGVWSEKGQVEVFALRRLLQVVEEPQALAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQITQWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGETELKELHWHPQCPGLLVSTALSGFTIFRTISV","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":446,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9BQ67","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The growth regulation by estrogen in breast cancer protein (GRWD1) has a role in DNA replication and chromatin remodeling. As an approximately 52 kDa protein GRWD1 interacts with several key cellular components. It is notably expressed in tissues with high cell turnover such as the liver and spleen indicating its role in actively dividing cells. This protein expression suggests it has a significant part in cell proliferation.
Biological function summary

GRWD1 plays a role in chromatin structure modulation and ribosome biogenesis. GRWD1 is part of the histone chaperone complex impacting the correct assembly of chromatin during DNA replication and repair. This function assists cells in maintaining genomic stability which is important during active transcription and replication processes. Additionally its role in ribosome biogenesis helps ensure that cells produce sufficient proteins during growth phases.

Pathways

GRWD1 is involved in the DNA replication checkpoint and ribosome assembly pathways. It interacts with several regulatory proteins including cyclins and CDKs as part of these processes highlighting its involvement in the cell cycle. GRWD1 is part of the pathway with other proteins like RPA and MCMs ensuring DNA is accurately replicated and cell growth progresses smoothly during the cell cycle.

GRWD1 links to cancer through its involvement in chromatin remodeling defects. Dysregulation or mutations in GRWD1 can contribute to oncogenesis including breast cancer. Its association with proteins such as p53 underlines the importance of its correct function in preventing unregulated cell proliferation. Additionally irregularities in GRWD1 have been connected to ribosomopathies further implicating it in conditions resulting from aberrant ribosome assembly.
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일반 정보

기능

Histone binding-protein that regulates chromatin dynamics and loading of minichromosome maintenance (MCM) complex at replication origins, possibly by promoting chromatin openness (PubMed : 25990725). Plays a role in ribosomal biogenesis (PubMed : 15885502).

Subcellular localisation

Nucleus

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제품 프로토콜

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타겟 정보

Histone binding-protein that regulates chromatin dynamics and loading of minichromosome maintenance (MCM) complex at replication origins, possibly by promoting chromatin openness (PubMed : 25990725). Plays a role in ribosomal biogenesis (PubMed : 15885502).
See full target information GRWD1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

mBio 12:e0343121 PubMed34933446

2021

GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.

Applications

Unspecified application

Species

Unspecified reactive species

Shan Wei,Songjian Lu,Lifan Liang,Xian Wang,Wan Li,Tingting Li,Luping Chen,Enguo Ju,Xinquan Zhang,Zhao Lai,Yufei Huang,Xinghua Lu,Shou-Jiang Gao
제품이 사용된 논문 모두 보기
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Product promise

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