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AB105621

Recombinant Human GSKIP protein (His tag N-Terminus)

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Recombinant Human GSKIP protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 139 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

C14orf129, HSPC210, GSKIP, GSK3B-interacting protein, GSK3beta interaction protein

1 이미지
SDS-PAGE - Recombinant Human GSKIP protein (His tag N-Terminus) (AB105621)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GSKIP protein (His tag N-Terminus) (AB105621)

15% SDS-PAGE analysis of ab105621 (3μg)

주요 정보

Purity

>95% SDS-PAGE

ab105621 was purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB325997

Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color) (AB325997)

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  • 0
Proteins & Peptides

AB276916

Recombinant Mouse Neuroligin 1 protein (His tag)

SDS-PAGE - Recombinant Mouse Neuroligin 1 protein (His tag) (AB276916)

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  • 0
Primary Antibodies

AB306534

Alexa Fluor® 647 Anti-c-Kit antibody [EPR24708-25]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-c-Kit antibody [EPR24708-25] (AB306534)

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  • 0
Proteins & Peptides

AB139216

Recombinant Human PGPEP1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human PGPEP1 protein (His tag N-Terminus) (AB139216)

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  • 0
Proteins & Peptides

AB276389

Recombinant Human FLRT1 protein (His tag)

SDS-PAGE - Recombinant Human FLRT1 protein (His tag) (AB276389)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

Previously labelled as HSPC210.
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMETDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS","proteinLength":"Full Length","predictedMolecularWeight":"17.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":139,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9P0R6","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GSKIP also known as GSK3β-interacting protein plays a role in the signaling pathways by acting as a scaffold for protein interactions. This protein has an approximate mass of 17 kDa. GSKIP is expressed in various tissues including the brain and heart suggesting its broad functional significance in different physiological contexts. Its ability to interact with Glycogen Synthase Kinase 3 (GSK3) and other proteins highlights its involvement in important cellular processes.
Biological function summary

The protein functions as a regulatory adapter anchoring key kinases to their target proteins. It interacts with GSK3β forming a stable complex that influences several signaling pathways. By modulating these interactions GSKIP plays a role in controlling cell growth differentiation and apoptosis. Its capacity to form complexes with other proteins enhances its functional versatility within the cell impacting numerous biological processes.

Pathways

GSKIP exerts a notable influence in the Wnt/β-catenin and Hedgehog signaling pathways. It interacts with GSK3β which is a critical component of these pathways regulating cellular processes like proliferation and development. By affecting the stability and activity of β-catenin GSKIP indirectly influences gene expression. Additionally its involvement in these pathways links it to other related proteins like Axin which help modulate signal transduction.

GSKIP has connections to cancer and neurodegenerative diseases partly due to its role in regulating GSK3β activity. Alterations in the pathways involving GSKIP can impact disease progression and response to treatment. In cancer dysregulation of the Wnt pathway through GSKIP interactions may lead to abnormal cell proliferation. In neurodegenerative diseases its interaction with GSK3β relates to the phosphorylation of tau protein a significant aspect of Alzheimer's disease pathology.
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일반 정보

기능

A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed : 16981698, PubMed : 25920809, PubMed : 27484798). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed : 16981698, PubMed : 27484798). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed : 25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed : 19830702).

서열 유사성

Belongs to the GSKIP family.

Post-translational modifications

Phosphorylated by GSK3B.

Subcellular localisation

Nucleus

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제품 프로토콜

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타겟 정보

A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed : 16981698, PubMed : 25920809, PubMed : 27484798). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed : 16981698, PubMed : 27484798). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed : 25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed : 19830702).
See full target information GSKIP
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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