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AB180332

Recombinant Human GTSF1 protein (His tag N-Terminus)

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Recombinant Human GTSF1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 167 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

FAM112B, GTSF1, Gametocyte-specific factor 1, Protein FAM112B

1 이미지
SDS-PAGE - Recombinant Human GTSF1 protein (His tag N-Terminus) (AB180332)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GTSF1 protein (His tag N-Terminus) (AB180332)

15% SDS-PAGE analysis of ab180332 (3μg).

주요 정보

Purity

>90% SDS-PAGE

ab180332 is purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Primary Antibodies

AB262937

Anti-GTSF1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GTSF1 antibody (AB262937)

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Proteins & Peptides

AB282405

Recombinant Human SERPINE1 Protein (Active)

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Proteins & Peptides

AB229600

Recombinant human Amphiregulin protein (Active)

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Functional Studies - Recombinant human Amphiregulin protein (Active) (AB229600)

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Proteins & Peptides

AB236185

Recombinant Human RRP2 protein (His tag)

Mass Spectrometry - Recombinant Human RRP2 protein (His tag) (AB236185)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEETYTDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVASKLATCPFNARHQVPRAEISHHISSCDDRSCIEQDVVNQTRSLRQETLAESTWQCPPCDEDWDKDLWEQTSTPFVWGTTHYSDNNSPASNIVTEHKNNLASGMRVPKSLPYVLPWKNNGNAQ","proteinLength":"Full Length","predictedMolecularWeight":"21.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":167,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WW33","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GTSF1 also known as gametocyte specific factor 1 functions mechanically in the regulation of gene expression particularly in the germ cells. It is a protein with a molecular mass of approximately 29 kDa. GTSF1 expresses mainly in the testes and ovaries suggesting its role in reproductive biology. This target's interaction with nucleic acids is an important part of its function as it plays a role in maintaining genomic stability during gametogenesis.
Biological function summary

In the context of germ cell development GTSF1 interacts with the Piwi-interacting RNA (piRNA) pathway. It is part of a larger protein complex that influences RNA silencing playing a significant role in repressing transposable elements. This activity helps protect the integrity of the genome by preventing harmful genetic instability. The protein complex involving GTSF1 is important for the correct progression of gametogenesis impacting fertility and reproductive success.

Pathways

The involvement of GTSF1 in the piRNA pathway is essential for the silencing mechanism that targets transposable elements. This pathway is integral to maintaining germ cell genome integrity. GTSF1 works alongside other proteins like PIWI which aids in assembling the piRNA-induced silencing complex (piRISC). Through this involvement GTSF1 contributes to a downstream effect on various biosynthesis and protective mechanisms that ensure proper cell cycle progression.

Disrupted GTSF1 function is linked to reproductive health issues including infertility. Defects in piRNA pathway components related to GTSF1 failure may result in germ cell apoptosis or suboptimal gamete production. Furthermore malfunction in GTSF1 interactions could relate to gynecological disorders. GTSF1's interaction with PIWI proteins also ties it to cancer as abnormalities in piRNA pathways are sometimes observed in tumorigenesis due to their role in genomic stability.
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일반 정보

기능

Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.

서열 유사성

Belongs to the UPF0224 (FAM112) family.

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제품 프로토콜

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타겟 정보

Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.
See full target information GTSF1
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Product promise

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