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AB63120

Recombinant Human Haptoglobulin beta protein

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Recombinant Human Haptoglobulin beta protein is a Human Full Length protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.
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SDS-PAGE - Recombinant Human Haptoglobulin beta protein (AB63120)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Haptoglobulin beta protein (AB63120)

SDS page analysis of ab63120

주요 정보

Purity

>95% SDS-PAGE

발현 시스템

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P00738-1

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

Constituents: 50% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB234592

Prestained Protein Ladder - Extra broad molecular weight (6.5 - 270 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (6.5 - 270 kDa) (AB234592)

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Proteins & Peptides

AB276330

Recombinant Human Hemopexin protein (His tag)

SDS-PAGE - Recombinant Human Hemopexin protein (His tag) (AB276330)

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Primary Antibodies

AB272755

Anti-Haptoglobin antibody [EPR22856-71] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-Haptoglobin antibody [EPR22856-71] - BSA and Azide free (Capture) (AB272755)

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Proteins & Peptides

AB283925

Recombinant Human C-Reactive Protein/CRP Protein

SDS-PAGE - Recombinant Human C-Reactive Protein/CRP Protein (AB283925)

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Assay Kits

AB108856

Human Haptoglobin ELISA Kit

Competitive ELISA - Human Haptoglobin ELISA Kit (AB108856)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P00738","tags":[]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Haptoglobulin beta also known as Hp beta is a component of the haptoglobulin protein which binds free hemoglobin released from erythrocytes. This prevents oxidative damage to tissues. Haptoglobulin has a molecular mass of approximately 40 to 45 kDa depending on glycosylation. It is mainly expressed in the liver and then secreted into the bloodstream acting as an acute-phase protein during inflammatory responses.
Biological function summary

Haptoglobulin beta plays an important role in hemoglobin transport by forming a stable complex with free hemoglobin therefore facilitating its clearance by macrophages. This protein is a part of the haptoglobin-hemoglobin complex which is essential for preventing kidney damage and conserving iron after red blood cell lysis. Its biological function highlights its significance in the body's defense against oxidative stress.

Pathways

Haptoglobulin beta is involved in iron recycling and inflammation regulation. The hemoglobin scavenger receptor CD163 mediates the uptake of the haptoglobin-hemoglobin complex playing an important role in the iron metabolism pathway and immune system functioning. Additionally haptoglobulin is connected to the acute-phase response pathway alongside proteins like serum amyloid A to moderate inflammation and tissue protection.

Haptoglobulin beta links to hemolytic anemia and cardiovascular disease. A deficiency or polymorphism in the haptoglobulin gene can exacerbate complications in these conditions due to impaired hemoglobin scavenging. Heme released in absence of effective haptoglobulin activity promotes oxidative damage and inflammation contributing to disease pathology. C-reactive protein often interacts with haptoglobulin in the inflammatory network highlighting its multifaceted role in disease processes.
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일반 정보

기능

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

서열 유사성

Belongs to the peptidase S1 family.

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제품 프로토콜

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타겟 정보

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
See full target information HP

대체 명칭 보기

Haptoglobin, Zonulin, HP
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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