JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB239441

Recombinant Human HGD protein (His tag)

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Recombinant Human HGD protein (His tag) is a Human Full Length protein, in the 1 to 445 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

HGO, HGD, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase

1 이미지
SDS-PAGE - Recombinant Human HGD protein (His tag) (AB239441)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human HGD protein (His tag) (AB239441)

ab239441 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Escherichia coli

Tags

6x His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

style
left-column

보완 제품

Proteins & Peptides

AB238371

Recombinant Wheat Trypsin/alpha-amylase inhibitor CMx1/CMx3 protein (Tagged)

SDS-PAGE - Recombinant Wheat Trypsin/alpha-amylase inhibitor CMx1/CMx3 protein (Tagged) (AB238371)

  • 0
  • 0
Proteins & Peptides

AB276786

Recombinant Mouse TR-1 protein (Fc Chimera)

SDS-PAGE - Recombinant Mouse TR-1 protein (Fc Chimera) (AB276786)

  • 0
  • 0
Proteins & Peptides

AB163782

Recombinant Human VISTA protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human VISTA protein (GST tag N-Terminus) (AB163782)

  • 0
  • 0
Proteins & Peptides

AB216228

Recombinant human B7H4 protein (Fc Chimera Active)

Bioactive

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

서열 정보

[{"linker":null,"sequence":"MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSWLYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLCGAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEICVIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVPGGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPGGGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLDENYHKCWEPLKSHFTPNSRNPAEPN","proteinLength":"Full Length","predictedMolecularWeight":"54 kDa","actualMolecularWeight":null,"aminoAcidEnd":445,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q93099","tags":[{"tag":"6x His","terminus":"N-Terminus"}]}]
style
left-column

특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

HGD also known as homogentisate oxidase is an important enzyme involved in the catabolism of aromatic amino acids like tyrosine and phenylalanine. This enzyme possesses a molecular mass of roughly 50 kDa. In the human body HGD is expressed predominantly in the liver and kidney tissues. Its primary role is to catalyze the conversion of homogentisic acid into maleylacetoacetic acid a vital step in the breakdown process of these amino acids.
Biological function summary

The role of HGD is essential in maintaining proper amino acid metabolism. It does not directly form part of larger enzymatic complexes but acts as a standalone enzyme that facilitates a specific reaction in the breakdown pathway. This specific reaction aids in preventing the accumulation of intermediary metabolites that could cause cellular toxicity. By regulating the levels of homogentisic acid HGD ensures cellular homeostasis is maintained.

Pathways

The function of HGD fits into several metabolic processes related to amino acid degradation. Most notably it operates within the tyrosine degradation pathway a critical series of reactions required for energy production and detoxification in the body. HGD activity is intricately linked with enzymes like tyrosine aminotransferase which helps initiate the tyrosine breakdown and fumarylacetoacetate hydrolase which serves in the terminal steps of this pathway.

Improper functioning of HGD is directly associated with alkaptonuria a rare hereditary disorder causing the accumulation of homogentisic acid in body tissues. This condition often leads to arthritic complications and kidney stones. The dysfunction of this enzymatic pathway can also indirectly affect vitamin D metabolism highlighting the importance of HGD's efficient operation. In alkaptonuria the insufficient activity of HGD leads to an elevation of homogentisic acid affecting downstream pathways and interacting proteins critical for maintaining skeletal and renal health.
style
left-column

일반 정보

기능

Catalyzes the conversion of homogentisate to maleylacetoacetate.

서열 유사성

Belongs to the homogentisate dioxygenase family.

style
left-column

제품 프로토콜

style
left-column

타겟 정보

Catalyzes the conversion of homogentisate to maleylacetoacetate.
See full target information HGD
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com