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AB226407

Recombinant Human HNRNPM protein (Tagged)

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(2 제품이 사용된 논문 )

Recombinant Human HNRNPM protein (Tagged) is a Human Full Length protein, in the 2 to 730 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

HNRPM, NAGR1, HNRNPM, Heterogeneous nuclear ribonucleoprotein M, hnRNP M

1 이미지
SDS-PAGE - Recombinant Human HNRNPM protein (Tagged) (AB226407)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human HNRNPM protein (Tagged) (AB226407)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab226407 with 5% enrichment gel and 15% separation gel.

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB234617

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB234617)

  • 0
  • 0
Primary Antibodies

AB70492

Anti-hnRNP K antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hnRNP K antibody (AB70492)

  • 0
  • 0
Primary Antibodies

AB184787

Anti-Caspase-3 antibody [EPR18297]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-3 antibody [EPR18297] (AB184787)

  • 3
  • 3
Proteins & Peptides

AB123212

Recombinant Human hnRNP A1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human hnRNP A1 protein (His tag N-Terminus) (AB123212)

  • 0
  • 0
Primary Antibodies

AB129200

Anti-Nucleolin antibody [EPR7952]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nucleolin antibody [EPR7952] (AB129200)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"AAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA","proteinLength":"Full Length","predictedMolecularWeight":"93.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":730,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P52272","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The heterogeneous nuclear ribonucleoprotein M (HNRNPM) is a multifunctional RNA-binding protein also known as glycoprotein p37. It belongs to the hnRNP family. HNRNPM has a molecular mass of approximately 72 kDa. This protein is ubiquitously expressed in various tissues with higher levels in organs like the brain kidney and liver. HNRNPM localizes mainly in the nucleus but shuttles between the nucleus and cytoplasm depending on its phosphorylation state and the cellular context.
Biological function summary

HnRNP M plays key roles in RNA splicing RNA stability and the transport of mRNA molecules from the nucleus to the cytoplasm. It acts as part of the spliceosome complex and interacts with pre-mRNA to regulate alternative splicing which is essential for generating protein diversity. HNRNPM influences the exon inclusion or exclusion in the pre-mRNA affecting the formation of mature mRNA. This regulation capability connects it with processes such as gene expression and cellular response to external signals.

Pathways

HNRNPM has significant roles in RNA splicing and processing pathways. Its involvement in alternative splicing links it to the regulation of the MAPK/ERK signaling pathway. In these pathways HNRNPM coordinates with other proteins like SR proteins and other hnRNP family members ensuring efficient mRNA maturation and transport. These activities highlight its importance in maintaining proper cellular functioning and responding to signaling events.

Research connects HNRNPM to cancer and neurodegenerative diseases. Abnormal expression or mutations in HNRNPM associate with tumor progression metastasis and poor prognosis in various cancers. It often interacts with proteins like E-cadherin and beta-catenin impacting cell adhesion and migration. Additionally dysregulation of HNRNPM expression might contribute to the pathogenesis of neurodegenerative conditions like Alzheimer's disease potentially linking it to proteins such as amyloid precursor protein (APP) through altered RNA processing activities.
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일반 정보

기능

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

Post-translational modifications

Sumoylated.

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제품 프로토콜

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타겟 정보

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
See full target information HNRNPM
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancers 15: PubMed38001611

2023

Circular RNA from Tyrosylprotein Sulfotransferase 2 Gene Inhibits Cisplatin Sensitivity in Head and Neck Squamous Cell Carcinoma by Sponging miR-770-5p and Interacting with Nucleolin.

Applications

Unspecified application

Species

Unspecified reactive species

Tianqing Wang,Chuan Xin,Shiyu Zhang,Xin Tian,Yuting Hu,Ying Wang,Jiongke Wang,Ning Ji,Xin Zeng,Jing Li

Scientific reports 12:10568 PubMed35732702

2022

SILAC kinase screen identifies potential MASTL substrates.

Applications

Unspecified application

Species

Unspecified reactive species

Kamila A Marzec,Samuel Rogers,Rachael McCloy,Benjamin L Parker,David E James,D Neil Watkins,Andrew Burgess
제품이 사용된 논문 모두 보기
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Product promise

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