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AB276637

Recombinant Human HP-3 protein (Fc Chimera)

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Recombinant Human HP-3 protein (Fc Chimera) is a Human Full Length protein, in the 39 to 94 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

DEF3, DEFA3, Neutrophil defensin 3, HNP-3, HP-3, HP3

1 이미지
SDS-PAGE - Recombinant Human HP-3 protein (Fc Chimera) (AB276637)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human HP-3 protein (Fc Chimera) (AB276637)

SDS-PAGE analysis of ab276637

주요 정보

Purity

>95% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

Fc tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS

storage-buffer

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

서열 정보

[{"linker":null,"sequence":"DIPEVVVSLAWDESLAPKHPGSRKNMDCYCRIPACIAGERRYGTCIYQGRLWAFCC","proteinLength":"Full Length","predictedMolecularWeight":"34.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":94,"aminoAcidStart":39,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P59666","tags":[{"tag":"Fc","terminus":"N-Terminus"}]}]

특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

HP-3 also known as Hematopoietic Protein 3 acts as an important component in various cellular activities. It has a molecular mass of approximately 47 kDa. The protein is highly expressed in hematopoietic tissues particularly in the bone marrow and spleen. HP-3 is also present in smaller amounts in the liver and peripheral blood. Its expression in these areas indicates its essential role in blood cell formation and function.
Biological function summary

HP-3 plays an important role in the regulation of hematopoiesis the process which produces blood cells. The protein is not part of a larger complex but interacts closely with other proteins to regulate cell differentiation and proliferation. Its regulatory action supports both the maintenance of self-renewing stem cells and the differentiation of various blood lineages. This dual functionality emphasizes the protein's contribution to the body’s ability to sustain healthy and balanced blood cell populations.

Pathways

This protein is involved in the hematopoietic pathway. It also plays a role in the JAK/STAT signaling pathway influencing the differentiation and proliferation of hematopoietic stem cells. HP-3 interacts with proteins such as STAT5 and JAK2 which are central to facilitating signals that promote growth and division within blood cells. This relationship highlights HP-3's involvement in the essential signaling processes that maintain blood homeostasis.

HP-3 shows significant connections to certain types of leukemia and anemia. Dysregulation or mutations of the HP-3 gene can lead to increased susceptibility or progression of acute myeloid leukemia. There is also an association with aplastic anemia a condition characterized by a failure of blood cell production. In these disorders HP-3 often interacts with proteins like FLT3 and EPO which also play roles in disease progression and therapeutic targeting. Understanding these connections can help guide better treatments and management strategies for affected patients.

일반 정보

기능

Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed : 15616305, PubMed : 15772169, PubMed : 17142766). Possesses the ability to neutralize bacterial toxins such as B.anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed : 15772169, PubMed : 18435932, PubMed : 25963798). Also blocks herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed : 17142766).

서열 유사성

Belongs to the alpha-defensin family.

제품 프로토콜

타겟 정보

Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed : 15616305, PubMed : 15772169, PubMed : 17142766). Possesses the ability to neutralize bacterial toxins such as B.anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed : 15772169, PubMed : 18435932, PubMed : 25963798). Also blocks herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed : 17142766).
See full target information DEFA3

Product promise

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