Recombinant Human HSPC152 protein (Tagged) is a Human Full Length protein, in the 1 to 125 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
대체 명칭 보기
AD-001, HSPC152, HSPC170, TRMT112, Multifunctional methyltransferase subunit TRM112-like protein, tRNA methyltransferase 112 homolog
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human HSPC152 protein (Tagged) (AB239546)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab239546 could indicate that this peptide derived from E.coli-expressed Human HSPC152.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human HSPC152 protein (Tagged) (AB239546)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab239546 could indicate that this peptide derived from E.coli-expressed human HSPC152 .
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human HSPC152 protein (Tagged) (AB239546)
ab239546 analysis by (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
보완 제품
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HSPC152 contributes to cellular homeostasis and regulation at multiple levels. While its standalone functions remain under investigation it is often involved as part of larger protein complexes. Studies have shown that it might interact with other proteins to influence cell cycle regulation implicating its potential role in maintaining cellular balance and responding to external stimuli.
Pathways
HSPC152 is associated with the regulatory processes in cell proliferation and apoptosis. It is speculated to interact within pathways such as the PI3K-Akt signaling pathway which is essential for cell survival. Connections between HSPC152 and proteins such as Akt and mTOR suggest it may contribute to modulating these pathways impacting varied cellular responses in different tissues.
일반 정보
기능
Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed : 18539146, PubMed : 20308323, PubMed : 25851604, PubMed : 31061526, PubMed : 31328227, PubMed : 31636962, PubMed : 37283053). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed : 25851604). The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed : 18539146, PubMed : 31061526, PubMed : 31636962). The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1) (PubMed : 31061526). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed : 20308323). Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (PubMed : 34669960, PubMed : 37283053). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed : 25851604). Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed : 31328227, PubMed : 33428944, PubMed : 35033535, PubMed : 37283053).
서열 유사성
Belongs to the TRM112 family.
타겟 정보
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com