JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB92922

Recombinant Human IFITM2 protein (6x His + GST)

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Recombinant Human IFITM2 protein (6x His + GST) is a Human Full Length protein, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, ELISA, WB, Mass Spec.
1 이미지
SDS-PAGE - Recombinant Human IFITM2 protein (6x His + GST) (AB92922)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human IFITM2 protein (6x His + GST) (AB92922)

ab92922 analysed on 10% SDS-PAGE and stained with Coomassie Blue (1) or detected by western blot analysis with an antibody to the proprietary tag (2).

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Escherichia coli

Tags

6x His tag GST tag

Applications

Mass Spec, WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

Q01629-1

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Preservative: 0.68% Imidazole Constituents: 2.9% Sodium chloride, 0.316% Tris HCl, 0.0078% 2-Mercaptoethanol

storage-buffer

style
left-column

보완 제품

Proteins & Peptides

AB95927

Recombinant human NEDD4 protein (DDDDK tag N-Terminus)

Functional Studies - Recombinant human NEDD4 protein (DDDDK tag N-Terminus) (AB95927)

  • 0
  • 0
Proteins & Peptides

AB316475

Recombinant Human SORL1 Protein Standard (His tag)

Sandwich ELISA - Recombinant Human SORL1 Protein Standard (His tag) (AB316475)

  • 0
  • 0
Proteins & Peptides

AB314611

Recombinant Human AQP5 Protein (His Tag)

SDS-PAGE - Recombinant Human AQP5 Protein (His Tag) (AB314611)

  • 0
  • 0
Proteins & Peptides

AB163206

Recombinant Human Transmembrane protein 30A (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Transmembrane protein 30A (GST tag N-Terminus) (AB163206)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

서열 정보

[{"linker":null,"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q01629","tags":[{"tag":"6x His","terminus":""},{"tag":"GST","terminus":""}]}]
style
left-column

특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The IFITM2 protein also known as Interferon-Induced Transmembrane Protein 2 is a member of the IFITM family which includes IFITM1 and IFITM3. IFITM2 has a molecular mass of approximately 14 kDa. It is found mainly in the plasma membrane and is expressed in various tissues notably immune cells. It functions as part of the cellular response to viral infections acting mechanically to restrict virus entry into the host cell and prevent replication of various viruses.
Biological function summary

The role of IFITM2 extends beyond mechanical blocking as it participates in the immune response by inhibiting the fusion of viral membranes with endosomal membranes. IFITM2 operates together with IFITM1 and IFITM3 forming a complex that boosts its antiviral capacity. The protein contributes to the defense mechanism against a broad range of viral pathogens including influenza and dengue viruses.

Pathways

Research shows that IFITM2 is involved in the interferon signaling pathway which regulates immune response to pathogens. In this pathway IFITM proteins are part of the type I and type II interferon responses enhancing cellular resistance to viral infection. The protein collaborates with others such as STAT1 in maintaining cellular defenses against pathogens.

Several studies have connected IFITM2 to influenza and other viral infections. Altered function or expression of IFITM2 could relate to increased susceptibility to some viral infections or influence the disease progression. The interacts with proteins such as IFITM3 further implicating its involvement in the clinical outcomes of these viral diseases.
style
left-column

제품 프로토콜

style
left-column

타겟 정보

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed : 26354436, PubMed : 33563656). Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed : 26354436, PubMed : 33239446, PubMed : 33270927, PubMed : 33563656). Can inhibit : influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed : 33563656). Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed : 26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed : 26354436).
See full target information IFITM2

대체 명칭 보기

Interferon-induced transmembrane protein 2, Dispanin subfamily A member 2c, Interferon-inducible protein 1-8D, DSPA2c, IFITM2
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com