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AB214609

Recombinant Human IL-24 protein (Fc Chimera)

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Recombinant Human IL-24 protein (Fc Chimera) is a Human Full Length protein, in the 53 to 207 aa range, expressed in CHO cells, with >98%, < 0.06 EU/µg endotoxin level, suitable for SDS-PAGE.

주요 정보

Purity

>98% SDS-PAGE

Endotoxin 레벨

< 0.06 EU/µg

발현 시스템

CHO cells

Tags

Human IgG1 Fc tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q13007-2

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute at 100µg/ml in sterile PBS.

보관 버퍼

Constituents: PBS

storage-buffer

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보완 제품

Proteins & Peptides

AB275556

Recombinant Human Thyroid Peroxidase/TPO protein (His tag)

SDS-PAGE - Recombinant Human Thyroid Peroxidase/TPO protein (His tag) (AB275556)

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Proteins & Peptides

AB316624

Recombinant Human Ribonuclease 3 Protein Standard (His tag)

Sandwich ELISA - Recombinant Human Ribonuclease 3 Protein Standard (His tag) (AB316624)

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Proteins & Peptides

AB191969

Recombinant Human IL-20R2 protein (Fc Chimera)

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Primary Antibodies

AB124332

Anti-IL-20R2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-20R2 antibody (AB124332)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":207,"aminoAcidStart":53,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q13007","tags":[{"tag":"Human IgG1 Fc","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle|Stable for 12 months at -20°C
False
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일반 정보

기능

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed : 25168428, PubMed : 27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed : 27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed : 11706020, PubMed : 30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed : 25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).

서열 유사성

Belongs to the IL-10 family.

Post-translational modifications

Glycosylated.. Ubiquitination at Lys-122 promotes proteasomal degradation.

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제품 프로토콜

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타겟 정보

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed : 25168428, PubMed : 27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed : 27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed : 11706020, PubMed : 30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed : 25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
See full target information IL24

대체 명칭 보기

MDA7, ST16, Interleukin-24, IL-24, Melanoma differentiation-associated gene 7 protein, Suppression of tumorigenicity 16 protein, MDA-7
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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