Recombinant Human ILT-7 protein (His tag) is a Human Fragment protein, in the 1 to 446 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
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CD85g, ILT7, LILRA4, Leukocyte immunoglobulin-like receptor subfamily A member 4, CD85 antigen-like family member G, Immunoglobulin-like transcript 7, ILT-7
- SDS-PAGE
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SDS-PAGE - Recombinant Human ILT-7 protein (His tag) (AB276712)
SDS-PAGE analysis of ab276712
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ILT-7 plays an important role in the regulation of type I interferon production in dendritic cells. This receptor forms a complex with the Fc epsilon RI gamma chain which transmits activation signals inside the cell. In resting conditions ILT-7 helps maintain immune homeostasis by regulating the release of interferons therefore balancing immune activation and controlling potential overactivity that might lead to autoimmunity.
Pathways
ILT-7 interacts within the signaling network of toll-like receptor (TLR) pathways. It closely ties with TLR9 a protein that recognizes unmethylated CpG motifs often found in viral DNA enhancing the production of interferons during viral infections. This collaboration establishes a link between pathogen recognition and immune response modulation within dendritic cells assisting in orchestrating a potent defense against viral pathogens.
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기능
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed : 16735691, PubMed : 19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed : 16735691, PubMed : 19564354, PubMed : 24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed : 26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed : 16735691, PubMed : 19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed : 24586760).
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