Recombinant Human ING2 protein (GST tag N-Terminus)

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ING2 also known as Inhibitor of Growth Protein 2 is a nuclear protein with a molecular weight of approximately 33 kDa. It expresses highly in tissues such as the prostate placenta and lung. Nuclear localization signals and PHD-finger motifs characterize its structure allowing it to bind to chromatin and influence gene expression. As a member of the ING family ING2 plays a role in regulating various cellular processes through its presence in different cellular compartments.

Biological function summary

ING2 functions as a tumor suppressor by controlling the transcription of genes involved in cell cycle regulation and apoptosis. It interacts with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes contributing to chromatin remodeling. As part of the Sin3A-HDAC complex ING2 has the ability to repress transcription influencing the expression of genes important for maintaining cellular homeostasis and preventing oncogenesis.

Pathways

The ING2 protein actively participates in the p53 signaling pathway as well as the MAPK signaling pathway. Its interaction with p53 leads to the enhancement of p53-mediated transcriptional activation which promotes cell cycle arrest and apoptosis. ING2 also interacts with proteins like TP53 and EP300 modulating the cellular responses to stress signals and contributing to cell survival and repair mechanisms.

The involvement of ING2 has been linked to cancer and neurodegenerative disorders. In cancer downregulation or mutation of ING2 disrupts the p53 pathway leading to impaired tumor suppression. ING2's interaction with TP53 and its tumor suppressor role highlights its importance in cancer biology. Furthermore in neurodegenerative disorders ING2's dysregulation can influence neuronal survival pathways potentially affecting proteins like p53 and EP300 therefore altering neuronal function and contributing to disease progression.