AB163384

Recombinant Human INPP5E protein (GST tag N-Terminus)

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Recombinant Human INPP5E protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 644 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

Phosphatidylinositol polyphosphate 5-phosphatase type IV, 72 kDa inositol polyphosphate 5-phosphatase, Inositol polyphosphate-5-phosphatase E, INPP5E

1 이미지

SDS-PAGE - Recombinant Human INPP5E protein (GST tag N-Terminus) (AB163384)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human INPP5E protein (GST tag N-Terminus) (AB163384)

ab163384 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Applications

ELISA, WB

applications

Biologically active

Accession

Animal free

Carrier free

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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서열 정보

[{"linker":null,"sequence":"MPSKAENLRPSEPAPQPPEGRTLQGQLPGAPPAQRAGSPPDAPGSESPALACSTPATPSGEDPPARAAPIAPRPPARPRLERALSLDDKGWRRRRFRGSQEDLEARNGTSPSRGSVQSEGPGAPAHSCSPPCLSTSLQEIPKSRGVLSSERGSPSSGGNPLSGVASSSPNLPHRDAAVAGSSPRLPSLLPPRPPPALSLDIASDSLRTANKVDSDLADYKLRAQPLLVRAHSSLGPGRPRSPLACDDCSLRSAKSSFSLLAPIRSKDVRSRSYLEGSLLASGALLGADELARYFPDRNVALFVATWNMQGQKELPPSLDEFLLPAEADYAQDLYVIGVQEGCSDRREWETRLQETLGPHYVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSGDGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEVFWFGDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGSIFKGFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYRSRHKGDICPVSYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLLGIKRRISKEIQRQQALQSQNSSTICSVS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":644,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NRR6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Proprietary technique

배송 시 보관 조건

Dry Ice

적절한 단기 보관 조건

-80°C

적절한 장기 보관 조건

-80°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

False

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

INPP5E also known as type I inositol polyphosphate-5-phosphatase plays a significant role as an enzyme regulating phosphoinositide signaling. This protein has a molecular mass of approximately 72 kDa. INPP5E cleaves the 5-phosphate from phosphoinositides affecting cellular processes. It is widely expressed in various tissues with notable presence in the brain and testis indicating its importance in these tissue types.

Biological function summary

INPP5E is involved in maintaining phosphoinositide balance within cells which regulates cellular signaling pathways. It is essential for the function of primary cilia by controlling ciliary membrane composition. This protein often interacts with components of the ciliary transition zone forming part of the complex that regulates trafficking proteins and movement.

Pathways

INPP5E engages in the phosphoinositide signaling pathway and the ciliary signaling pathway. It influences the activity of proteins such as phosphatidylinositol and adenylyl cyclase playing a role in signaling cascades that affect cell metabolism and spatial orientation. Disruption in its function can alter these signaling pathways demonstrating its importance in cellular communication and function.

Studies link INPP5E to Joubert syndrome and Meckel syndrome conditions affecting ciliary function. These ciliopathies are marked by abnormal brain development and a range of other symptoms. INPP5E interacts with proteins like ARL13B and CEP290 which are also associated with these disorders highlighting its integral role in maintaining healthy ciliary architecture and function.

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일반 정보

기능

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed : 10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed : 10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity).

서열 유사성

Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type IV family.

Subcellular localisation

Cytoskeleton

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제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information Phosphatidylinositol polyphosphate 5-phosphatase type IV

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Recombinant Human INPP5E protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human INPP5E protein (GST tag N-Terminus) (AB163384)

주요 정보

발현 시스템

Tags

Applications

Biologically active

Accession

Animal free

Carrier free

Species

보관 버퍼

보완 제품

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Proteins & Peptides

Reactivity 정보

서열 정보

특성 및 보관 정보

제형

Purification 테크닉

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

일반 정보

기능

서열 유사성

Subcellular localisation

제품 프로토콜

타겟 정보

Product promise