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AB164779

Recombinant Human Invadolysin protein (GST tag N-Terminus)

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Recombinant Human Invadolysin protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 655 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

Leishmanolysin-like peptidase, Invadolysin, LMLN

1 이미지
SDS-PAGE - Recombinant Human Invadolysin protein (GST tag N-Terminus) (AB164779)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Invadolysin protein (GST tag N-Terminus) (AB164779)

ab164779 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Primary Antibodies

AB281584

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001]

20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunocytochemistry/ Immunofluorescence - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001] (AB281584)

  • 5
  • 4
Primary Antibodies

AB5103

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

  • 4
  • 28
Primary Antibodies

AB219407

Anti-Histone H3 (citrulline R17) antibody [EPR20358-120]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-Histone H3 (citrulline R17) antibody [EPR20358-120] (AB219407)

  • 5
  • 1
Primary Antibodies

AB310335

Anti-Neutrophil Elastase antibody [EPR28386-66]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Advanced Validation

Multiplex immunohistochemistry - Anti-Neutrophil Elastase antibody [EPR28386-66] (AB310335)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MVTTLGPKMAAEWGGGVGYSGSGPGRSRWRWSGSVWVRSVLLLLGGLRASATSTPVSLGSSPPCRHHVPSDTEVINKVHLKANHVVKRDVDEHLRIKTVYDKSVEELLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQCATNQYLRKENDPHRYCTGECAAHTKCGPVIVPEEHLQQCRVYRGGKWPHGAVGVPDQEGISDADFVLYVGALATERCSHENIISYAAYCQQEANMDRPIAGYANLCPNMISTQPQEFVGMLSTVKHEVIHALGFSAGLFAFYHDKDGNPLTSRFADGLPPFNYSLGLYQWSDKVVRKVERLWDVRDNKIVRHTVYLLVTPRVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNRVLSRITLALMEDTGRQMLSPYCDTLRSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELSGIPAEDLPYYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILENQPEIFKNYGAEKYGPHSVCLIQKSAFVMEKCERKLSYPDWGSGCYQVSCSPQGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFCELCPPETDPPATNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFLLCIWH","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":655,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96KR4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Invadolysin also known as KIAA0174 or NET39 is a serine protease involved in cell migration and invasion. This enzyme has a mass of approximately 90 kDa. Invadolysin expresses in various tissues including those of the nervous system where it plays a role in development. In several cancer cells higher expression levels suggest a role in tumor progression. Its presence in cellular membrane structures indicates its importance in cellular interactions and movement.
Biological function summary

Invadolysin facilitates cell motility by remodeling the extracellular matrix and promoting cytoskeletal changes. It acts within protease complexes that regulate cellular processes like division and differentiation. In the nervous system invadolysin aids in neurodevelopment by guiding neural cells to their proper destinations. Its role in angiogenesis the formation of new blood vessels highlights its significance in tissue growth and repair processes.

Pathways

Research shows invadolysin's involvement in the MAPK signaling and Wnt pathways both important for cell growth and division. Within these pathways invadolysin interacts with proteins such as ERK and β-catenin influencing cellular adhesion and proliferation. Its activity within these pathways highlights its role in transmitting signals that direct cell behavior and fate.

Studies link invadolysin to cancer and neurodegenerative disorders. Its upregulation in cancers like melanoma and breast cancer suggests its role in promoting metastasis. In Alzheimer's disease dysregulated invadolysin activity may disrupt cellular processes contributing to neuronal death. Connections with proteins like tau in neurodegenerative disorders highlight the enzyme's potential impact on diseases characterized by protein aggregation and cellular dysfunction.
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일반 정보

기능

Metalloprotease.

서열 유사성

Belongs to the peptidase M8 family.

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제품 프로토콜

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타겟 정보

Metalloprotease.
See full target information LMLN
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Product promise

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