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AB160598

Recombinant Human IQ motif containing B1 protein (GST tag N-Terminus)

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Recombinant Human IQ motif containing B1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 465 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

KIAA0036, NPHP5, OK/SW-cl.85, IQCB1, IQ calmodulin-binding motif-containing protein 1, Nephrocystin-5, p53 and DNA damage-regulated IQ motif protein, PIQ

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SDS-PAGE - Recombinant Human IQ motif containing B1 protein (GST tag N-Terminus) (AB160598)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human IQ motif containing B1 protein (GST tag N-Terminus) (AB160598)

ab160598 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Primary Antibodies

AB241197

Anti-IQ motif containing B1 antibody

Immunoprecipitation - Anti-IQ motif containing B1 antibody (AB241197)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MKPTGTDPRILSIAAEVAKSPEQNVPVILLKLKEIINITPLGSSELKKIKQDIYCYDLIQYCLLVLSQDYSRIQGGWTTISQLTQILSHCCVGLEPGEDAEEFYNELLPSAAENFLVLGRQLQTCFINAAKAEEKDELLHFFQIVTDSLFWLLGGHVELIQNVLQSDHFLHLLQADNVQIGSAVMMMLQNILQINRSKRSKMLLEINRQKEEEDLKLQLQLQRQRAMRLSRELQLSMLEIVHPGQVEKHYREMEEKSALIIQKHWRGYRERKNFHQQRQSLIEYKAAVTLQRAALKFLAKYRKKKKLFAPWRGLQELTDARRVELKKRVDDYVRRHLGSPMSDVVSRELHAQAQERLQHYFMGRALEERAQQHREALIAQISTNVEQLMKAPSLKEAEGKEPELFLSRSRPVAAKAKQAHLTTLKHIQAPWWKKLGEESGDEIDVPKDELSIELENLFIGGTKPP","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":465,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q15051","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

IQ motif containing B1 also known as IQCB1 or NPHP5 is a protein that functions mechanically as a part of cellular pathways involving microtubule dynamics. This protein has an approximate mass of 69 kDa and is widely expressed in various tissues with higher levels noted in the retina and kidney. The function of IQCB1 is closely related to its role in intracellular transport and sensory cilia signaling.
Biological function summary

IQ motif containing B1 plays an important role in the ciliary transition zone which is an important component in cilia formation and function. This protein is part of a protein complex known as the nephronophthisis module where it collaborates with other proteins to maintain ciliary structural integrity. Defects or mutations in IQCB1 may disrupt this module highlighting its significance in normal cellular operations.

Pathways

The IQ motif containing B1 is involved in the ciliogenesis and cilia function pathways. In these pathways it interacts with proteins such as NPHP6 (also known as CEP290) to regulate ciliary assembly and ensure proper signal transduction. IQCB1's function is essential for the proper maintenance of these pathways which are critical for sensory perception and cellular communication.

Mutations in IQ motif containing B1 are linked to conditions such as nephronophthisis and retinitis pigmentosa. The protein's interaction with other proteins like RPGR which is associated with retinitis pigmentosa emphasizes its role in multi-systemic diseases affecting the kidneys and eyes. Understanding the function and interaction of IQCB1 with these proteins provides insights into the mechanisms underlying these disorders and may guide future therapeutic strategies.
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일반 정보

기능

Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed : 21565611, PubMed : 23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed : 25552655).

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제품 프로토콜

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타겟 정보

Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed : 21565611, PubMed : 23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed : 25552655).
See full target information IQCB1
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Product promise

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