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AB59954

Recombinant Human IRF2 protein (His tag N-Terminus)

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Recombinant Human IRF2 protein (His tag N-Terminus) is a Human Fragment protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.
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SDS-PAGE - Recombinant Human IRF2 protein (His tag N-Terminus) (AB59954)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human IRF2 protein (His tag N-Terminus) (AB59954)

ab59954 on 15%SDS-PAGE (3µg)

주요 정보

Purity

>95% SDS-PAGE

using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P14316-1

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.242% Tris, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Primary Antibodies

AB124744

Anti-IRF2 antibody [EPR4644(2)]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2 antibody [EPR4644(2)] (AB124744)

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  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLP","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P14316","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Interferon Regulatory Factor 2 (IRF2) also known as IRF-2 plays an important role in cellular processes like modulation of immune responses and regulation of gene expression. It has a molecular mass of approximately 39 kDa. IRF2 is expressed across various tissues including the immune system cells fibroblasts and epithelial cells. It can function as both a transcriptional activator and repressor depending on the context and specific gene targets.
Biological function summary

IRF2 regulates immune responses by controlling the expression of interferon (IFN) responsive genes. It acts independently and as part of transcriptional complexes binding to specific DNA sequences within target genes. Its action prevents excessive activation of immune responses maintaining a balanced immune system. IRF2 also influences cell cycle regulation contributing to its role in cell growth and differentiation.

Pathways

And several cellular communication networks IRF2 is a central figure in the interferon signaling pathway interacting with other members of the IRF family like IRF1 and IRF3. These interactions help propagate signals necessary for effective immune responses. In conjunction with the JAK-STAT pathway IRF2 modulates expressions that control antiviral responses and cellular proliferation showing its critical placement in immune response regulation.

IRF2's dysregulation has associations with cancer and autoimmune diseases. Overexpression of IRF2 is linked to certain cancers providing cells with growth advantages and resistance to apoptosis commonly in concert with proteins like STAT1. In autoimmune diseases IRF2 impacts inflammatory responses with aberrant regulation contributing to conditions like systemic lupus erythematosus. Its involvement highlights the complex nature of immune regulation and potential for targeted therapy interventions.
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일반 정보

기능

DNA-binding transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible genes and regulates their expression (PubMed : 39013473, PubMed : 7687740). Mainly acts as a transcription repressor, repressing expression (PubMed : 39013473). Also acts as an activator for several genes including H4 and IL7 (PubMed : 15226432, PubMed : 9540062). Constitutively binds to the ISRE promoter to activate IL7 (PubMed : 15226432). Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth (PubMed : 9540062). Antagonizes IRF1 transcriptional activation (By similarity).. Isoform 2. Unable to bind to IRF2BP1 and IRF2BP2 corepressors and cannot mediate repression.

서열 유사성

Belongs to the IRF family.

Post-translational modifications

Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.. The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.

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제품 프로토콜

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타겟 정보

DNA-binding transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible genes and regulates their expression (PubMed : 39013473, PubMed : 7687740). Mainly acts as a transcription repressor, repressing expression (PubMed : 39013473). Also acts as an activator for several genes including H4 and IL7 (PubMed : 15226432, PubMed : 9540062). Constitutively binds to the ISRE promoter to activate IL7 (PubMed : 15226432). Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth (PubMed : 9540062). Antagonizes IRF1 transcriptional activation (By similarity).. Isoform 2. Unable to bind to IRF2BP1 and IRF2BP2 corepressors and cannot mediate repression.
See full target information IRF2

대체 명칭 보기

Interferon regulatory factor 2, IRF-2, IRF2
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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