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AB256095

Recombinant Human ITLN1 protein (Animal Free)

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Recombinant Human ITLN1 protein (Animal Free) is a Human Full Length protein, in the 1 to 313 aa range, expressed in Escherichia coli, with >95%, <1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

INTL, ITLN, LFR, UNQ640/PRO1270, ITLN1, Intelectin-1, ITLN-1, Endothelial lectin HL-1, Galactofuranose-binding lectin, Intestinal lactoferrin receptor, Omentin

1 이미지
SDS-PAGE - Recombinant Human ITLN1 protein (Animal Free) (AB256095)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ITLN1 protein (Animal Free) (AB256095)

SDS-PAGE analysis of ab256095 (1 μg) under reducing (Lane 1) and non-reducing (Lane 2) conditions.

4-20% Tris-Glycine gel. Coomassies Blue staining.

주요 정보

Purity

>95% SDS-PAGE

Endotoxin 레벨

<1 EU/µg

발현 시스템

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

Yes

Carrier free

No

Species

Human

Reconstitution

Reconstitute at 0.1 mg/mL in water

보관 버퍼

Constituents: Mannitol, 0.16% Sodium phosphate

storage-buffer

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보완 제품

Primary Antibodies

AB187167

Anti-IL-11 antibody [EPR15253]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-IL-11 antibody [EPR15253] (AB187167)

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Primary Antibodies

AB254470

Anti-ITLN1 + ITLN2 antibody [EPR22491-81] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITLN1 + ITLN2 antibody [EPR22491-81] - BSA and Azide free (AB254470)

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Assay Kits

AB269545

Human Omentin ELISA Kit (ITLN1)

Recombinant|SimpleStep

Sandwich ELISA - Human Omentin ELISA Kit (ITLN1) (AB269545)

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Primary Antibodies

AB7202

Anti-MCP1 antibody

Flow Cytometry (Intracellular) - Anti-MCP1 antibody (AB7202)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MNQLSFLLFLIATTRGWSTDEANTYFKEWTCSSSPSLPRSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGSKADYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLGHNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQCGDFSGFDWSGYGTHVGYSSSREITEAAVLLFYR","proteinLength":"Full Length","predictedMolecularWeight":"35 kDa","actualMolecularWeight":null,"aminoAcidEnd":313,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WWA0","tags":[]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ITLN1 also known as 'omentin-1' or 'omentin' is a carbohydrate-binding protein mainly involved in the recognition and binding of microbial polysaccharides. This protein weighs approximately 36 kDa and is predominantly expressed in visceral fat and other tissues such as the heart lungs and placenta. ITLN1 functions as an adipokine a signaling molecule released by fat tissue and it plays a significant role in regulating glucose metabolism and insulin sensitivity.
Biological function summary

This target contributes to various important processes related to inflammatory and immune responses. ITLN1 is part of a complex network of interactions involving lectin receptors and other carbohydrate-binding proteins. It functions in response to pathogens by recognizing and trapping them thereby aiding in pathogen clearance. Its anti-inflammatory effects are mediated through its capacity to bind to ligands found on the surface of bacteria therefore preventing their adhesion and invasion.

Pathways

ITLN1 interacts with the insulin signaling and inflammation pathways. It has a direct relation with the PI3K/Akt pathway known to play roles in glucose uptake and metabolism. This interaction has a connection to proteins like insulin receptor substrate-1 (IRS-1) through this pathway. Additionally ITLN1 engages with adipocytokine pathways impacting processes like lipid metabolism and inflammation.

Researchers have found links between ITLN1 and metabolic diseases particularly type 2 diabetes and obesity. Reduced levels of ITLN1 correlate with poor metabolic control and increased risk for these conditions. Moreover its expression and secretion tend to alter in response to inflammation linking it with inflammatory disorders and processes. Other proteins such as adiponectin also involve themselves in these metabolic pathways providing insight into their interconnected roles in metabolic homeostasis.
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일반 정보

기능

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed : 11313366, PubMed : 26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed : 26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed : 26148048). Does not bind human glycans (PubMed : 26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed : 16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed : 16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed : 11747454, PubMed : 23921499).

Post-translational modifications

N-glycosylated.

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제품 프로토콜

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타겟 정보

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed : 11313366, PubMed : 26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed : 26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed : 26148048). Does not bind human glycans (PubMed : 26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed : 16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed : 16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed : 11747454, PubMed : 23921499).
See full target information ITLN1
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Product promise

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