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AB140589

Recombinant Human KCTD11/REN protein (denatured) (His tag N-Terminus)

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Recombinant Human KCTD11/REN protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 232 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

C17orf36, REN, KCTD11, BTB/POZ domain-containing protein KCTD11, KCASH1 protein, Potassium channel tetramerization domain-containing protein 11, RING-type E3 ubiquitin transferase subunit KCTD11

1 이미지
SDS-PAGE - Recombinant Human KCTD11/REN protein (denatured) (His tag N-Terminus) (AB140589)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human KCTD11/REN protein (denatured) (His tag N-Terminus) (AB140589)

15% SDS-PAGE analysis of ab140589 (3μg).

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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보완 제품

Primary Antibodies

AB309229

Anti-GBA antibody [EPR26755-42] - BSA and Azide free (Detector)

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-GBA antibody [EPR26755-42] - BSA and Azide free (Detector) (AB309229)

  • 0
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Primary Antibodies

AB181258

Anti-STIM2 antibody [EPR12879] - C-terminal

RabMAb|Recombinant|Trial Size

Western blot - Anti-STIM2 antibody [EPR12879] - C-terminal (AB181258)

  • 0
  • 0
Primary Antibodies

AB235513

Anti-CEP63 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP63 antibody (AB235513)

  • 0
  • 0
Primary Antibodies

AB126204

Anti-Apc10 antibody

Western blot - Anti-Apc10 antibody (AB126204)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

This product was previously labelled as KCTD11
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMLGAMFRAGTPMPPNLNSQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRELEASQGTPAPTAALLHADVDVSPRLVHFSARRGPHHYELSSVQVDTFRANLFCTDSECLGALRARFGVASGDRAEGSPHFHLEWAPRPVELPEVEYGRLGLQPLWTGGPGERREVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH","proteinLength":"Full Length","predictedMolecularWeight":"28 kDa","actualMolecularWeight":null,"aminoAcidEnd":232,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q693B1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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일반 정보

기능

Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.

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제품 프로토콜

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타겟 정보

Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
See full target information KCTD11
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Product promise

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