Recombinant Human KLHL22 protein (GST tag N-Terminus)

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Biological function summary

KLHL22 is involved in regulating protein turnover by targeting proteins for ubiquitination influencing processes such as cell cycle progression and signal transduction. It operates as an adaptor protein within the Cullin-RING E3 ubiquitin ligase complex linking substrate proteins to the complex for ubiquitination. By regulating the degradation of key proteins KLHL22 impacts cellular homeostasis and various physiological responses demonstrating its importance in maintaining cellular order.

Pathways

KLHL22 contributes to the ubiquitin-proteasome pathway where it assists in protein degradation and turnover maintaining protein quality control. It also associates with the cell cycle regulation pathway interacting with proteins such as CUL3 within the Cullin-RING complex to ensure cell cycle progression by timely degradation of cyclins and other regulatory proteins. These pathway involvements highlight KLHL22's role in cellular regulation and proteostasis.