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AB161621

Recombinant Human LARS2 protein (GST tag N-Terminus)

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Recombinant Human LARS2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 903 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

KIAA0028, LARS2, Leucyl-tRNA synthetase, LeuRS

1 이미지
SDS-PAGE - Recombinant Human LARS2 protein (GST tag N-Terminus) (AB161621)
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Supplier Data

SDS-PAGE - Recombinant Human LARS2 protein (GST tag N-Terminus) (AB161621)

ab161621 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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  • 20
Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

  • 0
  • 0
Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

  • 0
  • 0
Proteins & Peptides

AB161146

Recombinant Human BS69 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BS69 protein (GST tag N-Terminus) (AB161146)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"sequence":"MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":903,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q15031","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LARS2 also known as mitochondrial leucyl-tRNA synthetase 2 plays a significant role in protein biosynthesis. This enzyme is part of the class II aminoacyl-tRNA synthetase family with a molecular mass of around 108 kDa. LARS2 primarily functions in mitochondria ensuring the proper attachment of leucine to its corresponding tRNA an essential step for protein translation. Expression of LARS2 occurs most notably in tissues with high metabolic demands such as muscle and liver where mitochondrial activity is important.
Biological function summary

LARS2 facilitates the translation of mitochondrial-encoded proteins by charging tRNA with leucine. It operates as a monomer and does not participate in a larger complex. This charging process is essential for maintaining mitochondrial function and energy production ensuring the correct synthesis of respiratory chain components. LARS2 thereby provides support for the translation machinery within mitochondria.

Pathways

LARS2 plays an indispensable role within the mitochondrial translation system. It directly influences the oxidative phosphorylation pathway by enabling the synthesis of components important for electron transport and ATP production. LARS2 interacts functionally with other mitochondrial tRNA synthetases like GARS2 and YARS2 contributing to the efficient translation of proteins fundamental for cellular respiration.

Mutations in the LARS2 gene have been linked to Perrault syndrome a condition characterized by ovarian dysgenesis and sensorineural deafness. Additionally disruptions in LARS2 activity may also contribute to mitochondrial encephalopathy. The dysfunction of LARS2 affects proteins within the mitochondrial oxidative phosphorylation pathway impacting ATP production and cellular energy balance which further associates with disorders involving METTL1 and other mitochondrial synthetases impacting similar processes.
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일반 정보

기능

Catalyzes the attachment of leucine to its cognate tRNA.

서열 유사성

Belongs to the class-I aminoacyl-tRNA synthetase family.

Subcellular localisation

Mitochondrion matrix

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제품 프로토콜

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타겟 정보

Catalyzes the attachment of leucine to its cognate tRNA.
See full target information LARS2
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Product promise

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