Recombinant Human LCE3A protein (His tag)

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The late cornified envelope 3A (LCE3A) protein is a member of the LCE3 cluster with a molecular mass of approximately 10 kDa. The LCE3A gene is located on chromosome 1q21 in the epidermal differentiation complex and is expressed highly in the epidermis specifically in the outermost layers of skin. LCE3A features in the formation of the cornified cell envelope which is significant for the barrier function of the skin. This protein supports skin integrity by interacting with structural proteins such as involucrin and loricrin.

Biological function summary

LCE3A plays an integral role in skin barrier repair and maintenance. It does not appear as part of a larger protein complex but functions with related LCEs to enhance skin resilience. LCE3A is important in rapid response to skin injury where it aids in restoring the protective outer skin layer. The protein's presence ensures a flexible yet robust barrier capable of management of moisture retention and pathogen resistance. This function accentuates its value in maintaining healthy skin physiology.

Pathways

LCE3A engages in the epidermal development and differentiation pathways. It works closely with structural proteins and enzymes involved in the cornification and keratinization processes like filaggrin and transglutaminases. These pathways enable efficient skin barrier formation and contribute to the dynamic process of skin regeneration. The interconnected roles of these proteins highlight their importance in establishing a competent skin barrier responsive to environmental challenges and repair needs.

LCE3A has a recognized association with psoriasis and potential involvement in other skin-related conditions. LCE3A expression loss or dysfunction links with impaired skin barrier contributing to the development of psoriasis. Related proteins such as LCE3B and LCE3C also contribute to this condition by influencing barrier integrity. Understanding LCE3A's role in skin physiology aids in exploring therapeutic targets for treating or managing psoriasis or similar skin pathologies.