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AB158828

Recombinant Human LRP1 protein (GST tag N-Terminus)

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Recombinant Human LRP1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 292 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

대체 명칭 보기

CD91, A2MR, APR, LRP1, Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, APOER

1 이미지
SDS-PAGE - Recombinant Human LRP1 protein (GST tag N-Terminus) (AB158828)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human LRP1 protein (GST tag N-Terminus) (AB158828)

ab158828 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB325994

Prestained Protein Ladder - Mid-range molecular weight (11-180 kDa, 4-color)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (11-180 kDa, 4-color) (AB325994)

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  • 0
Primary Antibodies

AB92544

Anti-LRP1 antibody [EPR3724]

BOND RX™ Validated|20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-LRP1 antibody [EPR3724] (AB92544)

  • 5
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Assay Kits

AB278128

Human LRP1 ELISA Kit

Recombinant|SimpleStep

ELISA - Human LRP1 ELISA Kit (AB278128)

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Proteins & Peptides

AB162688

Recombinant Human LRP1B protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human LRP1B protein (GST tag N-Terminus) (AB162688)

  • 0
  • 0
Primary Antibodies

AB221155

Anti-Filaggrin antibody [EPR21892]

BOND RX™ Validated|20ul selling size|Recombinant|Advanced Validation|RabMAb

Multiplex immunohistochemistry - Anti-Filaggrin antibody [EPR21892] (AB221155)

  • 5
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHLCVFSKSQQEMG","proteinLength":"Full Length","predictedMolecularWeight":"58 kDa","actualMolecularWeight":null,"aminoAcidEnd":292,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q07954","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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일반 정보

기능

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed : 11907044, PubMed : 12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed : 1702392, PubMed : 26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed : 32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed : 12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed : 9252371).. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

서열 유사성

Belongs to the LDLR family.

Post-translational modifications

Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.. The N-terminus is blocked.. Phosphorylated on serine and threonine residues.. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.

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제품 프로토콜

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타겟 정보

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed : 11907044, PubMed : 12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed : 1702392, PubMed : 26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed : 32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed : 12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed : 9252371).. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
See full target information LRP1
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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