Recombinant Human LSM3 protein (His tag N-Terminus)

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LSM3 also known as U6 snRNA-associated Sm-like protein LSm3 is a core component of the SMN-Sm complex. It has a molecular mass of about 10 kDa. LSM3 shows expression across various tissues with notable levels in the cytoplasm and nucleus. Its structure includes multiple Sm motifs responsible for RNA binding essential for its role in snRNP assembly.

Biological function summary

LSM3 works in forming part of the heptameric LSM protein complex. This complex plays an important role in RNA processing particularly in the stabilization and degradation of mRNA. LSM3 aids the functioning of U6 snRNA which is involved in pre-mRNA splicing a vital step in gene expression. It actively participates in the assembly and disassembly of pre-mRNA splicing machinery influencing mRNA turnover.

Pathways

LSM3 interacts significantly with spliceosomal pathways. It cooperates with proteins such as LSM2 and LSM4 facilitating the U6 snRNP assembly. LSM3 is integral to the mRNA decay pathway influencing how mRNAs are processed or degraded after undergoing splicing. Its interactions within these pathways highlight its role in post-transcriptional regulation critical for gene expression control.

LSM3 has links to neurodegenerative diseases like spinal muscular atrophy. In this disorder LSM3’s interaction with the SMN protein responsible for snRNP assembly becomes compromised affecting motor neurons. Defects in the SMN complex can lead to improper gene splicing and expression contributing to disease pathology. Additionally LSM3 links to certain cancers due to its role in the regulation of mRNA splicing and stability impacting cell proliferation and survival.