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AB126656

Recombinant Human MAGEA6 protein (His tag C-Terminus)

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Recombinant Human MAGEA6 protein (His tag C-Terminus) is a Human Full Length protein, in the 1 to 314 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

MAGE6, MAGEA6, Melanoma-associated antigen 6, Cancer/testis antigen 1.6, MAGE-6 antigen, MAGE3B antigen, CT1.6

1 이미지
SDS-PAGE - Recombinant Human MAGEA6 protein (His tag C-Terminus) (AB126656)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MAGEA6 protein (His tag C-Terminus) (AB126656)

15% SDS-PAGE showing ab126656 (3µg).

주요 정보

Purity

>85% SDS-PAGE

ab126656 is purified using conventional chromatography techniques

발현 시스템

Escherichia coli

Tags

His tag C-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Proteins & Peptides

AB99138

Recombinant Human MAGEA4 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human MAGEA4 protein (His tag N-Terminus) (AB99138)

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Proteins & Peptides

AB202614

Recombinant Human MAGEA8 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human MAGEA8 protein (His tag N-Terminus) (AB202614)

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  • 0
Proteins & Peptides

AB99958

Recombinant Human MAGE3 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human MAGE3 protein (His tag N-Terminus) (AB99958)

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  • 0
Proteins & Peptides

AB124572

Recombinant Human MAGEA5 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human MAGEA5 protein (His tag N-Terminus) (AB124572)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQLVFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPEEKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEELEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"35.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":314,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P43360","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MAGEA6 also known as Melanoma Antigen Family A6 is a member of the MAGE gene family. This protein has a molecular mass of approximately 35 kDa. MAGEA6 is usually expressed in the testis and various types of tumors but shows limited expression in normal somatic tissues. Its expression in tumors makes it a potential target for cancer immunotherapy and biomarker research.
Biological function summary

MAGEA6 is involved in cellular processes relating to gene regulation and apoptosis. It interacts with other MAGE proteins and is often part of a larger multiprotein complex which influences gene transcription. The protein plays a role in cell survival and proliferation particularly in tumorous cells where it can aid in escape from immune surveillance.

Pathways

MAGEA6 participates in critical signaling pathways including the p53 pathway. This pathway is significant in regulating cell cycle arrest DNA repair and apoptosis. MAGEA6 can interact with proteins like p53 and MDM2 potentially modulating the tumor suppressor functions of p53. This interaction highlights its role in tumor pathogenesis as it can affect cell cycle regulation and apoptosis resistance.

MAGEA6 associates closely with cancers such as melanoma and ovarian cancer. Its expression in these cancers connects it to proteins like MAGEA1 and MAGEA3 which also have roles in cancer biology and immune evasion. The presence of MAGEA6 in tumors offers potential for it to be used as a cancer-specific antigen in various therapeutic strategies.
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일반 정보

기능

Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed : 17942928, PubMed : 20864041, PubMed : 31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3 : substrate complex (PubMed : 17942928, PubMed : 20864041). May play a role in tumor transformation or aspects of tumor progression (PubMed : 17942928, PubMed : 20864041). In vitro promotes cell viability in melanoma cell lines (PubMed : 17942928).

Post-translational modifications

Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation.

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제품 프로토콜

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타겟 정보

Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed : 17942928, PubMed : 20864041, PubMed : 31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3 : substrate complex (PubMed : 17942928, PubMed : 20864041). May play a role in tumor transformation or aspects of tumor progression (PubMed : 17942928, PubMed : 20864041). In vitro promotes cell viability in melanoma cell lines (PubMed : 17942928).
See full target information MAGEA6
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancers 16: PubMed39409926

2024

ANKRD1 Promotes Breast Cancer Metastasis by Activating NF-B-MAGE-A6 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Penchatr Diskul-Na-Ayudthaya,Seon Joo Bae,Yun-Ui Bae,Ngu Trinh Van,Wootae Kim,Seongho Ryu
제품이 사용된 논문 모두 보기
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Product promise

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