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AB165538

Recombinant Human MGAT5B protein (GST tag N-Terminus)

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Recombinant Human MGAT5B protein (GST tag N-Terminus) is a Human Fragment protein, in the 1 to 394 aa range, expressed in Wheat germ, suitable for ELISA, WB.
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SDS-PAGE - Recombinant Human MGAT5B protein (GST tag N-Terminus) (AB165538)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MGAT5B protein (GST tag N-Terminus) (AB165538)

ab165538 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q3V5L5-1

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Primary Antibodies

AB87977

Anti-MGAT5 antibody [3E9]

Flow Cytometry - Anti-MGAT5 antibody [3E9] (AB87977)

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Proteins & Peptides

AB219247

Recombinant Human ST6GAL1 protein (His tag C-Terminus)

SDS-PAGE - Recombinant Human ST6GAL1 protein (His tag C-Terminus) (AB219247)

  • 0
  • 0
Primary Antibodies

AB180578

Anti-MGAT1 antibody [EPR14247]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-MGAT1 antibody [EPR14247] (AB180578)

  • 5
  • 5
Proteins & Peptides

AB160437

Recombinant Human B4GALT5 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human B4GALT5 protein (GST tag N-Terminus) (AB160437)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MITVNPDGKIMVRRCLVTLRPFRLFVLGIGFFTLCFLMTSLGGQFSARRLGDSPFTIRTEVMGGPESRGVLRKMSDLLELMVKRMDALARLENSSELHRAGGDLHFPADRMPPGAGLMERIQAIAQNVSDIAVKVDQILRHSLLLHSKVSEGRRDQCEAPSDPKFPDCSGKVEWMRARWTSDPCYAFFGVDGTECSFLIYLSEVEWFCPPLPWRNQTAAQRAPKPLPKVQAVFRSNLSHLLDLMGSGKESLIFMKKRTKRLTAQWALAAQRLAQKLGATQRDQKQILVHIGFLTEESGDVFSPRVLKGGPLGEMVQWADILTALYVLGHGLRVTVSLKELQRQRRLRSSQEQARCGVMGACEKMLLEGDVASNTLLIEKPSKKETEKCPKNLVT","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":394,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q3V5L5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MGAT5B also known as beta-16-N-acetylglucosaminyltransferase 5B is an enzyme involved in glycosylation. This enzyme participates in the addition of N-acetylglucosamine to the core oligosaccharide of N-linked glycoproteins. MGAT5B has a mass of around 77 kDa. Expression of MGAT5B occurs mainly in the liver pancreas and certain tumor cells where it contributes to the creation of complex branched N-glycans. These glycan structures are important in modulating various cellular interactions and functions.
Biological function summary

Branching of N-glycans by MGAT5B influences cell signaling and cell adhesion. It plays a role in enhancing the motility and invasiveness of tumor cells where it contributes to cellular communication and profile changes. MGAT5B localizes to the Golgi apparatus where it acts as part of the N-glycan biosynthetic pathway but does not appear to form a stable complex with other enzymes. Its actions support processes that require flexible and functional cell membranes.

Pathways

MGAT5B participates in the N-glycan biosynthesis and the TGF-beta signaling pathway. Its actions leading to increased branches on N-glycans can enhance signaling pathways that regulate cell proliferation and differentiation. Related proteins such as TGF-beta interact with MGAT5B's products where branched glycans enhance the availability of receptors on the cell surface influencing the downstream signaling cascade.

MGAT5B has significant implications in cancer and diabetes. In cancer the overexpression of MGAT5B stabilizes cell surface receptor availability leading to heightened migratory and invasive capabilities especially related to proteins like TGF-beta which can contribute to metastasis. In diabetes alterations in glycosylation patterns due to MGAT5B's action can impact insulin receptor signaling with potential impacts observed through interaction with proteins like the insulin receptor itself.
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제품 프로토콜

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타겟 정보

Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.
See full target information MGAT5B

대체 명칭 보기

KIAA2008, MGAT5B, GlcNAc-T Vb, Mannoside acetylglucosaminyltransferase 5B, N-acetylglucosaminyl-transferase Vb, N-acetylglucosaminyltransferase IX, GNT-Vb, hGnTVb, GNT-IX
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록and refine your search

Annals of translational medicine 9:1312 PubMed34532449

2021

Identification and validation of a metabolism-related model and associated with tumor-infiltrating lymphocytes in p53 mutant lung adenocarcinoma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Chang Zheng,Liang Sun,Baosen Zhou,Aiping Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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