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AB158890

Recombinant Human MGST2 protein (GST tag N-Terminus)

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Recombinant Human MGST2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 147 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

GST2, MGST2, Microsomal glutathione S-transferase 2, Microsomal GST-2, Glutathione peroxidase MGST2, Leukotriene C4 synthase MGST2, Microsomal glutathione S-transferase II, Microsomal GST-II

1 이미지
SDS-PAGE - Recombinant Human MGST2 protein (GST tag N-Terminus) (AB158890)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MGST2 protein (GST tag N-Terminus) (AB158890)

ab158890 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Proteins & Peptides

AB158833

Recombinant Human LTC4S protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human LTC4S protein (GST tag N-Terminus) (AB158833)

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Primary Antibodies

AB259806

Anti-CD127 antibody [EPR23747-333]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD127 antibody [EPR23747-333] (AB259806)

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  • 1
Primary Antibodies

AB129012

Anti-COASY antibody [EPR8246]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-COASY antibody [EPR8246] (AB129012)

  • 4
  • 1
Primary Antibodies

AB109190

Anti-LI Cadherin antibody [EPR3996]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LI Cadherin antibody [EPR3996] (AB109190)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKKLRRQF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":147,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q99735","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Microsomal glutathione S-transferase 2 (MGST2) is an important enzyme involved in detoxification processes within the body. MGST2 is alternatively known as GST2 or FXC1. The protein has a molecular mass of approximately 13 kDa and is expressed in various tissues including the liver lungs and kidneys where it plays a significant role in defending cells against oxidative stress. It functions by catalyzing the conjugation of glutathione to toxic substances facilitating their removal from the body.
Biological function summary

MGST2 impacts cellular defense by aiding in the detoxification of harmful compounds. It operates as part of a larger complex often associating with other glutathione transferases. By facilitating the breakdown of reactive oxygen species and electrophiles MGST2 helps in protecting cells from damage. This protection is especially important in metabolically active tissues where reactive by-products are more frequent.

Pathways

MGST2 is a component of the glutathione metabolism pathway where it collaborates closely with related proteins such as GSTM1 and GSTT1. It also plays a role in the arachidonic acid metabolism pathway. MGST2 interacts with enzymes important for the synthesis of leukotrienes which are signaling molecules involved in the inflammatory response. These pathways highlight MGST2's role in maintaining cellular homeostasis and responding to stress.

MGST2 has been linked to certain conditions due to its role in detoxification and inflammation. Impaired function of this enzyme can be connected to liver disease where inefficient clearance of toxins can exacerbate hepatic damage. MGST2 has also been implicated in inflammatory diseases like asthma where its interaction with leukotriene-related proteins influences inflammatory pathways. Understanding MGST2's role in these diseases may offer insights into new therapeutic targets.
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일반 정보

기능

Catalyzes several different glutathione-dependent reactions (PubMed : 23409838, PubMed : 26066610, PubMed : 26656251, PubMed : 8703034, PubMed : 9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed : 23409838, PubMed : 9278457). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed : 23409838, PubMed : 8703034). Also catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed : 23409838, PubMed : 26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed : 26656251).

서열 유사성

Belongs to the MAPEG family.

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제품 프로토콜

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타겟 정보

Catalyzes several different glutathione-dependent reactions (PubMed : 23409838, PubMed : 26066610, PubMed : 26656251, PubMed : 8703034, PubMed : 9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed : 23409838, PubMed : 9278457). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed : 23409838, PubMed : 8703034). Also catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed : 23409838, PubMed : 26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed : 26656251).
See full target information MGST2
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Product promise

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