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AB241455

Recombinant Human MINPP1 protein (His tag)

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Recombinant Human MINPP1 protein (His tag) is a Human Full Length protein, in the 31 to 487 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

MIPP, UNQ900/PRO1917, MINPP1, Multiple inositol polyphosphate phosphatase 1

1 이미지
SDS-PAGE - Recombinant Human MINPP1 protein (His tag) (AB241455)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MINPP1 protein (His tag) (AB241455)

Analysis of ab241455 by (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Yeast

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Primary Antibodies

AB24182

Anti-MD2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MD2 antibody (AB24182)

  • 4
  • 15
Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

  • 5
  • 8
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"SLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLIQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVLEYLNDLKQYWKRGYGYTINSRSSCTLFQDIFQHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKKQMHRKFRSGLIVPYASNLIFVLYHCENAKTPKEQFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARANSTSDEL","proteinLength":"Full Length","predictedMolecularWeight":"54.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":487,"aminoAcidStart":31,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"Q9UNW1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

MINPP1 also known as multiple inositol polyphosphate phosphatase 1 functions as an enzyme that catalyzes the hydrolysis of inositol polyphosphates. Its molecular weight is approximately 49 kDa. MINPP1 is expressed widely across various tissues with high expression levels observed in the liver and kidney. This enzyme actively removes phosphate groups from specific inositol pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) which have a role in cellular functions.
Biological function summary

This enzyme modulates levels of inositol polyphosphate molecules key messengers in diverse cellular processes. MINPP1 impacts nuclear signaling and membrane trafficking affecting cellular communication. The enzyme acts independently and is not known to be part of a larger protein complex. Its activity can influence various cellular activities by regulating IP5 and IP6 levels hinting at its involvement in more intricate cellular networks.

Pathways

MINPP1 plays a role in phosphoinositide signaling and is involved in phosphate metabolism. These pathways are important for cell growth and survival. The enzyme's function can overlap with those of PTEN and INPP5 which also participate in phosphoinositide regulation. MINPP1 regulates key molecular signals impacting energy homeostasis and metabolic processes in cells.

Changes in MINPP1 function can relate to metabolic disorders and cancer. Malfunction or altered expression of this enzyme has associations with various cancers where its regulatory role on inositol phosphates is disrupted. PTEN another phosphatase involved in similar pathways often exhibits mutation in cancer suggesting potential parallel impacts when MINPP1 dysregulates. The enzyme's activity also influences disorders involving phosphate metabolism leading to potential therapeutic targets for such conditions.
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일반 정보

기능

Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed : 33257696, PubMed : 36589890). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant (PubMed : 36589890). By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed : 33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (PubMed : 18413611).

서열 유사성

Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

Post-translational modifications

N-glycosylated.

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제품 프로토콜

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타겟 정보

Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed : 33257696, PubMed : 36589890). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant (PubMed : 36589890). By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed : 33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (PubMed : 18413611).
See full target information MINPP1
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Product promise

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