Recombinant Human MIP-3 beta/CCL19 Protein is a Human Full Length protein, in the 22 to 98 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for HPLC, SDS-PAGE, Mass Spec.
대체 명칭 보기
ELC, MIP3B, SCYA19, CCL19, C-C motif chemokine 19, Beta-chemokine exodus-3, CK beta-11, Epstein-Barr virus-induced molecule 1 ligand chemokine, Macrophage inflammatory protein 3 beta, Small-inducible cytokine A19, EBI1 ligand chemokine, MIP-3-beta
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human MIP-3 beta/CCL19 Protein (AB307796)
Mass determination by ESI-TOF. Predicted MW is 8857.41 Da (+/- 10 Da by ESI-TOF). Observed MW is 8871.40 Da.
- HPLC
Supplier Data
HPLC - Recombinant Human MIP-3 beta/CCL19 Protein (AB307796)
HPLC analysis of ab307796
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human MIP-3 beta/CCL19 Protein (AB307796)
SDS-PAGE analysis of ab307796
보완 제품
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서열 정보
특성 및 보관 정보
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추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MIP-3 beta helps direct cell trafficking within the lymphoid organs. It is not part of a complex but its interaction with the CCR7 receptor is essential for its biological activity. This binding plays a role in the development of secondary lymphoid organs and immune surveillance. Furthermore MIP-3 beta supports the homing of immune cells to appropriate locations impacting both innate and adaptive immune responses.
Pathways
MIP-3 beta is associated with the chemokine signaling pathway and the immune system pathway. Through these pathways it interacts with proteins like CCR7 and other chemokines that regulate leukocyte migration and activation. These pathways ensure local and systemic immune responses are efficiently orchestrated impacting inflammation and immune regulation.
일반 정보
기능
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
서열 유사성
Belongs to the intercrine beta (chemokine CC) family.
타겟 정보
Product promise
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