Recombinant human MLK2 protein (GST tag N-Terminus)

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The MLK2 protein also known as MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) plays a role as a serine/threonine kinase. It weighs around 95 kDa and affects multiple intracellular signaling pathways. It is expressed in numerous tissues including the brain placenta and kidney. MLK2 features a catalytic domain typical of MAP3 kinases and a CRIB domain that interacts with small GTPases.

Biological function summary

This kinase influences cellular dynamics by partaking in the MAP kinase signal transduction cascade and is a component of signaling complexes. MLK2 is important in the regulation of cell proliferation differentiation and apoptosis. It primarily transduces signals originating from cell surface receptors through multi-step phosphorylation events affecting downstream effectors. MLK2 interacts with MAP kinase kinases (MKKs) to activate c-Jun N-terminal kinases (JNKs) and p38 pathways.

Pathways

MLK2 acts within the MAPK signaling and JNK pathways. It regulates responses to environmental stresses and cytokines therefore modulating cell fate. MLK2 has functional associations with proteins like JNKs and MKKs which play leading roles in these pathways. Furthermore it works in conjunction with other MAP3Ks to regulate MAPK signaling cascades tightly.

MLK2 shows associations with neurodegenerative diseases and cancer. Dysregulation of MLK2 kinase activity can contribute to the pathophysiology of Alzheimer's disease by affecting neuronal survival pathways. In various cancers altered MLK2 expression or function may lead to abnormal cell growth. These conditions often involve connections with proteins such as JNKs which are implicated in cellular stress responses and apoptotic pathways.