Recombinant Human N4BP2 protein (GST tag N-Terminus)

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N4BP2 also known as Nitrogen 4-binding protein 2 is a protein that displays specific binding activities. It has a calculated molecular weight of approximately 110-120 kDa. N4BP2 is expressed in various tissues including the brain liver and kidney. It plays a role in the regulation of cellular signaling pathways and can interact with multiple intracellular molecules allowing it to influence different cellular processes.

Biological function summary

The function of N4BP2 influences gene expression and the modulation of protein-protein interactions. It is known to be a component of larger protein complexes which are pivotal in cellular homeostasis. These complexes allow N4BP2 to participate in transcriptional regulation mechanisms and signal transduction pathways mediating responses to external and internal stimuli.

Pathways

N4BP2 integrates into both the ubiquitin-proteasome pathway and the immune response pathway. In the ubiquitin-proteasome pathway N4BP2 interacts with proteins such as ubiquitin-specific peptidases to regulate protein degradation important for cell cycle control and stress responses. Additionally in the immune response pathway it connects with signaling proteins that impact cytokine production and immune regulation contributing to the maintenance of immune homeostasis.

N4BP2 has associations with inflammatory diseases and certain types of cancer. It interacts with proteins like TNF receptor-associated factors in inflammation playing a role in cytokine signaling pathways that mediate inflammatory responses. In cancer alterations in the expression of N4BP2 or its interacting partners can influence tumor progression and metastasis marking it a potential therapeutic target for intervention.