Recombinant Human NAGA protein (His tag) is a Human Full Length protein, in the 1 to 411 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
대체 명칭 보기
Alpha-N-acetylgalactosaminidase, Alpha-galactosidase B, NAGA
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human NAGA protein (His tag) (AB276577)
SDS-PAGE analysis of ab276577
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
NAGA participates in the breakdown of complex sugar chains converting them into simpler molecules for further cellular use or disposal. This enzyme functions as a monomer not forming any known protein complexes. Its activity is necessary for the efficient turnover of biomolecules ensuring proper cellular function and maintenance of essential metabolic processes. Disordered NAGA activity may disrupt glycoconjugate breakdown resulting in cellular dysfunctions.
Pathways
NAGA contributes to lysosomal degradation pathways importantly the glycosaminoglycan (GAG) catabolism pathway. It works alongside other enzymes like alpha-N-acetylglucosaminidase and beta-galactosidase that sequentially degrade GAGs. NAGA’s function within the lysosomal degradation pathway highlights its role in maintaining cellular waste processing and recycling. Abnormalities in these pathways can affect cell health and dynamics emphasizing the enzyme's role in cellular metabolism.
일반 정보
기능
Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.
서열 유사성
Belongs to the glycosyl hydrolase 27 family.
Subcellular localisation
Lysosome
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