Recombinant Human NDP protein (denatured) (His tag N-Terminus)
Be the first to review this product! 리뷰 제출
|
(0 출판물)
Recombinant Human NDP protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 25 to 133 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.
대체 명칭 보기
EVR2, NDP, Norrin, Norrie disease protein, X-linked exudative vitreoretinopathy 2 protein
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human NDP protein (denatured) (His tag N-Terminus) (AB171607)
SDS-PAGE analysis of Recombinant Human NDP protein (denatured) (ab171607), under reducing conditions. Proteins visualized by coomassie blue stain.
Lane 1 : Molecular Weight Standards
Lane 2 : 3 μg Recombinant Human NDP protein (denatured)
보완 제품
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
NDP acts as a ligand that associates with the Frizzled-4 receptor and LRP5/6 to activate the Wnt/β-catenin signaling pathway. This activation leads to a variety of cellular responses such as cell proliferation and differentiation which are essential in vascular development. NDP exists within a complex that includes other Wnt pathway components ensuring precise regulation of these biological processes.
Pathways
The involvement of NDP in the Wnt/β-catenin signaling is significant for its regulation of vascular development and maintenance. It interacts with LRP5/6 and Frizzled-4 proteins within this pathway ensuring that endothelial cells form proper blood vessel structures. NDP also has implications within angiogenesis another vital pathway for the growth of new blood vessels enhancing the understanding of its function in vascular biology.
일반 정보
기능
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
타겟 정보
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com