Recombinant Human NEGR1 protein (His tag) is a Human Fragment protein, in the 1 to 324 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
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IGLON4, UNQ2433/PRO4993, NEGR1, Neuronal growth regulator 1, IgLON family member 4
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human NEGR1 protein (His tag) (AB276365)
SDS-PAGE analysis of ab276365
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
NEGR1 contributes to neuronal growth and connectivity. It forms part of the immunoglobulin superfamily which includes proteins involved in the immune response and cell adhesion processes. NEGR1 interacts with cellular membranes through a glycosylphosphatidylinositol anchor facilitating cell-cell communication and signaling necessary for neural network formation. This interaction allows NEGR1 to be a part of synaptic development and plasticity affecting learning and memory processes.
Pathways
NEGR1 plays a part in neuronal growth pathways and synaptic signaling. These pathways are important for the development and maintenance of neuronal circuits. NEGR1 has connections to the MAPK pathway which oversees cell differentiation and proliferation. It interacts with other synaptic proteins like Neurexins and Neuroligins which are important for synaptic formation and stability underlining its integrative role in neural development.
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기능
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
서열 유사성
Belongs to the immunoglobulin superfamily. IgLON family.
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