Recombinant Human NPDC1 protein (His tag)

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NPDC1 also known as Neural Proliferation Differentiation and Control protein 1 is a protein involved in inhibiting cell proliferation. It has a molecular mass of approximately 38 kDa. This protein finds expression mainly in the central nervous system particularly within neurons and shows variations in expression depending on developmental stage and cellular context. Its functional involvement in regulating cell cycle and neural differentiation makes it a significant player in neural development.

Biological function summary

NPDC1 plays a critical role in controlling the cell cycle and promoting neural differentiation. It does not typically form part of a large complex but it interacts with various molecules to execute its functions. NPDC1 helps modulate the activity of the retinoblastoma (Rb) pathway which is important for controlling cell cycle progression and differentiation. By regulating this pathway NPDC1 can influence cellular transformation events and maintain cellular homeostasis.

Pathways

NPDC1 significantly impacts neural cell cycle regulation and differentiation pathways. It strongly associates with the Rb pathway thereby impacting cell cycle checkpoints and differentiation signals. NPDC1 also shows interaction with proteins such as E2F transcription factors which play an important role in driving progression through the cell cycle. Its involvement in these pathways highlights its importance in maintaining proper neural development and growth.

NPDC1 shows potential relevance in neurological disorders and cancer. Aberrant expression or dysregulation of NPDC1 can lead to conditions such as neurodegenerative diseases including Alzheimer's disease where neural cell cycle control is disrupted. Additionally its interaction with Rb protein connects it to cancer pathways suggesting its potential involvement in gliomas and other neural-derived tumors. Understanding NPDC1's function and regulation can provide critical insights into these diseases and aid in developing targeted therapeutic strategies.