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AB160962

Recombinant Human NPM2 protein (GST tag N-Terminus)

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Recombinant Human NPM2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 214 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

Nucleoplasmin-2, NPM2

1 이미지
SDS-PAGE - Recombinant Human NPM2 protein (GST tag N-Terminus) (AB160962)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NPM2 protein (GST tag N-Terminus) (AB160962)

ab160962 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB116027

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB116027)

  • 5
  • 2
Primary Antibodies

AB243544

Anti-NPM2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPM2 antibody (AB243544)

  • 4
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMHRVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQERYEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKKLEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":214,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86SE8","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Nucleophosmin/Nucleoplasmin 2 (NPM2) also referred to as Nucleoplasmin-2 is a protein with molecular mass approximately 22 kDa. It belongs to the family of nucleoplasmins which are chromatin remodeling proteins. NPM2 is mainly expressed in oocytes and plays a significant role during early embryonic development. The protein is highly localized in the nuclei of developing oocytes and is known for its capacity to bind and exchange histones which is essential for chromatin structure.
Biological function summary

The function of NPM2 involves regulating chromatin in germ cells and early embryogenesis. It acts as a histone chaperone forming complexes with histones to facilitate chromatin assembly and disassembly. The protein enables the proper packing and unpacking of DNA ensuring genomic stability during cell division. NPM2 does not work alone and it often forms a complex with histone proteins allowing it to modulate chromatin dynamics efficiently.

Pathways

NPM2 participates in key cellular processes related to chromatin remodeling and regulation. It plays an important role in the chromatin assembly pathway working alongside proteins like histone H1 to modulate DNA accessibility. Additionally NPM2 interacts with other histone chaperones affecting the nucleosome assembly pathway. Through these pathways it influences various nuclear processes important for gene expression and maintenance of nuclear architecture.

NPM2 is associated with issues in reproductive health and cancer. Abnormal expression or malfunction of NPM2 can lead to infertility due to defects in oocyte maturation. In cancer biology variations in NPM2 expression levels might correlate with tumor progression where it interacts with several oncogenic proteins. For example changes in the function of NPM2 might influence the activity of histone-modifying enzymes linked to chromatin changes seen in malignant cells.
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일반 정보

기능

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.

서열 유사성

Belongs to the nucleoplasmin family.

Subcellular localisation

Nucleus

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제품 프로토콜

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타겟 정보

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
See full target information NPM2
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Product promise

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