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AB235810

Recombinant Human NPR-A protein (Tagged)

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Recombinant Human NPR-A protein (Tagged) is a Human Fragment protein, in the 33 to 473 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

ANPRA, NPR1, Atrial natriuretic peptide receptor 1, Atrial natriuretic peptide receptor type A, Guanylate cyclase A, ANP-A, ANPR-A, NPR-A, GC-A

3 이미지
Mass Spectrometry - Recombinant Human NPR-A protein (Tagged) (AB235810)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human NPR-A protein (Tagged) (AB235810)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235810 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NPR-A

Mass Spectrometry - Recombinant Human NPR-A protein (Tagged) (AB235810)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human NPR-A protein (Tagged) (AB235810)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235810 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NPR-A.

SDS-PAGE - Recombinant Human NPR-A protein (Tagged) (AB235810)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NPR-A protein (Tagged) (AB235810)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab235810.

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Proteins & Peptides

AB117019

Recombinant Human AGXT protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human AGXT protein (GST tag N-Terminus) (AB117019)

  • 0
  • 0
Primary Antibodies

AB139188

Anti-NPR-A + NPR-B antibody [EPR5719(2)]

RabMAb|Recombinant

Western blot - Anti-NPR-A + NPR-B antibody [EPR5719(2)] (AB139188)

  • 3
  • 1
Proteins & Peptides

AB112340

Recombinant Human Perilipin-1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Perilipin-1 protein (GST tag N-Terminus) (AB112340)

  • 0
  • 0
Proteins & Peptides

AB93935

Recombinant Human Apo-M protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Apo-M protein (His tag N-Terminus) (AB93935)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

Previously labelled as Natriuretic Peptide Receptor A.
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서열 정보

[{"linker":null,"sequence":"GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLE","proteinLength":"Fragment","predictedMolecularWeight":"64.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":473,"aminoAcidStart":33,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P16066","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NPR-A also known as natriuretic peptide receptor A is a guanylyl cyclase-linked receptor with a mass of approximately 120 kDa. It largely expresses in the kidney heart adrenal gland and vascular smooth muscle cells. NPR-A is structured to bind specifically with atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) facilitating signal transduction. This receptor generates cyclic GMP (cGMP) upon activation which acts as a secondary messenger in various cellular processes.
Biological function summary

Natriuretic peptide receptor A plays a significant role in cardiovascular homeostasis. NPR-A is not part of a larger complex but works closely with other natriuretic peptide systems to regulate blood pressure electrolyte balance and fluid homeostasis. Its activation results in diuresis natriuresis and vasodilation contributing to its function in maintaining cardiovascular health. Efficient functioning of NPR-A is essential for modulating cardiovascular responses.

Pathways

NPR-A is important in the cyclic GMP pathway and the ANP signaling pathway. It interacts with proteins like NPR-C and soluble guanylyl cyclase modulating key physiological responses. NPR-A impacts smooth muscle relaxation and renal function by influencing cGMP levels and related downstream pathways. Its role within these pathways is fundamental to maintaining vascular tone and sodium excretion.

NPR-A associates prominently with cardiovascular diseases such as hypertension and heart failure. In hypertension NPR-A dysregulation can impair proper sodium and water excretion exacerbating the condition. Heart failure involves altered signaling of NPR-A impacting cardiac and renal function. Protein interactions include altered expression of NPR-C affecting natriuretic peptide clearance and disease progression. Understanding NPR-A's function and regulation provides insights into its relationship with cardiovascular pathophysiology and potential therapeutic approaches.
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일반 정보

기능

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed : 39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed : 36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed : 36016499).

서열 유사성

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Post-translational modifications

Phosphorylation of the protein kinase-like domain is required for full activation by ANP.

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제품 프로토콜

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타겟 정보

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed : 39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed : 36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed : 36016499).
See full target information NPR1
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Product promise

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