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AB276735

Recombinant Human NRG2 protein (His tag)

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Recombinant Human NRG2 protein (His tag) is a Human Fragment protein, in the 112 to 404 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

NTAK, NRG2, Pro-NRG2

1 이미지
SDS-PAGE - Recombinant Human NRG2 protein (His tag) (AB276735)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NRG2 protein (His tag) (AB276735)

SDS-PAGE analysis of ab276735

주요 정보

Purity

>95% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS

storage-buffer

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보완 제품

Primary Antibodies

AB220615

Anti-NRG2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-NRG2 antibody (AB220615)

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Proteins & Peptides

AB52101

Recombinant human Cleaved Caspase-3 protein (Active)

Western blot - Recombinant human Cleaved Caspase-3 protein (Active) (AB52101)

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Biochemicals

AB120100

Kainic acid, prototypic kainate receptor agonist

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Secondary Antibodies

AB175775

Goat Anti-Mouse IgG H&L (Alexa Fluor® 680)

Western blot - Goat Anti-Mouse IgG H&L (Alexa Fluor® 680) (AB175775)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"CYSPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQK","proteinLength":"Fragment","predictedMolecularWeight":"34 kDa","actualMolecularWeight":null,"aminoAcidEnd":404,"aminoAcidStart":112,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O14511","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The NRG2 protein also known as neuregulin 2 belongs to the neuregulin family and is involved in cell communication. It possesses a mass of approximately 44 kDa. NRG2 is present in various tissues with notable expression in the central nervous system heart and skeletal muscles. Its structure includes an epidermal growth factor (EGF)-like domain which enables interaction with other proteins on cell surfaces.
Biological function summary

NRG2 is involved in neural development and synaptic plasticity. It associates with ErbB receptor tyrosine kinases to mediate cellular responses. NRG2 forms a complex with these receptors to trigger downstream signaling pathways that support nerve cell growth and repair. As a ligand it selectively binds to ErbB3 and ErbB4 initiating pathways important for brain homeostasis and function.

Pathways

The NRG2 protein plays a significant role in the PI3K/AKT signaling and MAPK/ERK pathways. These pathways are essential for regulating cell survival proliferation and differentiation. Through the ErbB receptors NRG2 influences these signaling pathways intimately connecting it with other proteins such as AKT1 in the PI3K/AKT pathway and MEK1/2 in the MAPK/ERK pathway which further amplify its regulatory roles in cellular processes.

NRG2 is implicated in schizophrenia and peripheral nerve diseases. The interaction of NRG2 with the ErbB4 receptor has associations with schizophrenia where alterations in this signaling pathway may affect cognitive functions. In peripheral nerve diseases NRG2's role in neuron repair and maintenance can be significant linking it to ErbB3 in supporting nerve regeneration processes which becomes vital when addressing neuropathies.
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일반 정보

기능

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

서열 유사성

Belongs to the neuregulin family.

Post-translational modifications

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.. Extensive glycosylation precedes the proteolytic cleavage.

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제품 프로토콜

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타겟 정보

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
See full target information NRG2
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Product promise

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