Recombinant Human NRXN3 protein (His tag) is a Human Fragment protein, in the 1 to 357 aa range, expressed in HEK 293 cells, with >94%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
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KIAA0743, NRXN3, Neurexin-3-beta, Neurexin III-beta
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human NRXN3 protein (His tag) (AB276438)
SDS-PAGE analysis of ab276438.
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Reagents, Controls & Accessories
AB325995
Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands)
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The protein contributes to the formation of complex structures in synapses. NRXN3 interacts with neuroligins and other postsynaptic proteins forming a bridge across the synaptic cleft. This interaction is essential for the alignment and stabilization of pre- and postsynaptic formations influencing synaptic transmission. The NRXN3 complex enables specific synaptic architecture affecting both excitatory and inhibitory synapses.
Pathways
NRXN3 plays a role in key neural signaling routes. It participates in the synaptic formation and plasticity pathways being important for both synaptogenesis and synaptic maintenance. NRXN3 shares pathway interactions with proteins such as neuroligin and dystroglycan. This alignment is important for regulating synapse stabilization and may influence the release of neurotransmitters across synaptic junctions.
일반 정보
기능
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response (By similarity).
서열 유사성
Belongs to the neurexin family.
Post-translational modifications
Processed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides.. O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins.
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