Recombinant Human NT5C3L protein (His tag N-Terminus)

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Biological function summary

NT5C3L plays a role in the degradation of RNA and DNA facilitating the recycling of nucleotides within cells. It does not form a part of a larger protein complex but works independently to regulate intracellular concentrations of pyrimidine nucleotides. By doing so it influences the balance between cell proliferation and apoptosis supporting the maintenance of cellular function and genomic stability. Its activity can impact on the synthesis and degradation pathways of nucleotides affecting overall cell health and viability.

Pathways

NT5C3L is an important participant in the pyrimidine metabolism pathway. It ensures an efficient turnover of pyrimidine nucleotides preventing toxic accumulation in cells. The enzyme interacts with other nucleotidases and kinases that manage nucleotide pools. It shares pathway relevance with proteins like NT5C3A and NT5C3B which also help in nucleoside phosphate metabolism. These connections ensure that nucleotide synthesis and salvage pathways work in harmony balancing nucleotide availability during cell division and repair processes.