JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB241530

Recombinant Human Nurr1 protein (His tag)

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Recombinant Human Nurr1 protein (His tag) is a Human Full Length protein, in the 1 to 598 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

NOT, NURR1, TINUR, NR4A2, Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor

1 이미지
SDS-PAGE - Recombinant Human Nurr1 protein (His tag) (AB241530)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Nurr1 protein (His tag) (AB241530)

SDS-PAGE - Recombinant Human Nurr1 protein (His tag) (ab241530)

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Yeast

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

style
left-column

보완 제품

Reagents, Controls & Accessories

AB325997

Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color) (AB325997)

  • 0
  • 0
Primary Antibodies

AB288067

Anti-TPH2 antibody [EPR25100-29]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Advanced Validation

Immunocytochemistry/ Immunofluorescence - Anti-TPH2 antibody [EPR25100-29] (AB288067)

  • 0
  • 0
Secondary Antibodies

AB150129

Donkey Anti-Goat IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (AB150129)

  • 5
  • 6
Sample Prep & Detection Kits

AB185913

High-Sensitivity ChIP Kit

ChIP - High-Sensitivity ChIP Kit (AB185913)

  • 0
  • 0
Primary Antibodies

AB305355

Anti-Nurr1 antibody [EPR24121-44] - BSA and Azide free (Detector)

RabMAb|Recombinant|KO Validated

Sandwich ELISA - Anti-Nurr1 antibody [EPR24121-44] - BSA and Azide free (Detector) (AB305355)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

서열 정보

[{"linker":null,"sequence":"MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF","proteinLength":"Full Length","predictedMolecularWeight":"68.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":598,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"P43354","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Nuclear receptor-related 1 protein (Nurr1) is a transcription factor weighing approximately 66 kDa. Scientists also know Nurr1 as NR4A2 and it belongs to the NR4A nuclear receptor family. Nurr1 is mainly expressed in the central nervous system where it plays a significant role in neuronal development and maintenance. Despite lacking a defined ligand-binding activity Nurr1 regulates gene expression directly by binding to DNA.
Biological function summary

Nurr1 functions as a critical regulator of dopaminergic neurons in the brain. It is vital for the survival and differentiation of these neurons which are important for motor control and behavioral responses. Nurr1 partners with other transcription factors often functioning in complexes that modulate brain-derived neurotrophic factor (BDNF) signaling. It influences the transcription of genes involved in inflammatory responses and neuroprotection reflecting its importance in maintaining neural health.

Pathways

Nurr1 integrates into key biological processes involving dopaminergic signaling and neuroinflammation. Nurr1 directly participates in the Wnt signaling pathway which plays a role in neuronal development and synaptic function. It also interacts with proteins such as Pitx3 and LMX1B within these pathways contributing to the regulation of dopaminergic neuron function and survival ultimately affecting broader central nervous system activity.

Nurr1 has strong associations with neurological conditions such as Parkinson’s disease and schizophrenia. Its impaired function or altered expression can lead to dopaminergic neuron degeneration a hallmark of Parkinson's disease. Research indicates Nurr1's interaction with parkin a protein implicated in the disease's pathology further emphasizes its importance. In schizophrenia altered Nurr1 activity affects synaptic regulation and cognitive function potentially relating to disrupted dopaminergic and BDNF pathways.
style
left-column

일반 정보

기능

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed : 15716272, PubMed : 17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

서열 유사성

Belongs to the nuclear hormone receptor family. NR4 subfamily.

style
left-column

제품 프로토콜

style
left-column

타겟 정보

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed : 15716272, PubMed : 17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
See full target information NR4A2
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com